Howard P. Isermann Department of Chemical and Biological Engineering and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Department of Mechanical, Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.
Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111247. doi: 10.1016/j.msec.2020.111247. Epub 2020 Jun 29.
In recent years, electrospun polymer fibers have gained attention for various antibacterial applications. In this work, the effect of positively charged polymer fiber mats as antibacterial gauze is studied using electrospun poly(caprolactone) and polyaniline nanofibers. Chloroxylenol, an established anti-microbial agent is used for the first time as a secondary dopant to polyaniline during the electrospinning process to make the surface of the polyaniline fiber positively charged. Both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli are used to investigate the antibacterial activity of the positively charged and uncharged polymer surfaces. The results surprisingly show that the polyaniline surface can inhibit the growth of both bacteria even when chloroxylenol is used below its minimum inhibitory concentration. This study provides new insights allowing the better understanding of dopant-based, intrinsically conducting polymer surfaces for use as antibacterial fiber mats.
近年来，电纺聚合物纤维因其在各种抗菌应用中的作用而受到关注。在这项工作中，使用电纺聚己内酯和聚苯胺纳米纤维研究了正电荷聚合物纤维垫作为抗菌纱布的效果。氯己定，一种已建立的抗菌剂，首次在电纺过程中用作聚苯胺的二次掺杂剂，使聚苯胺纤维表面带正电荷。使用革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌来研究正电荷和非电荷聚合物表面的抗菌活性。结果令人惊讶地表明，即使在低于最小抑菌浓度的情况下使用氯己定，聚苯胺表面也可以抑制两种细菌的生长。这项研究提供了新的见解，使我们能够更好地理解基于掺杂剂的本征导电聚合物表面作为抗菌纤维垫的用途。
