Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China; Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Environ Pollut. 2020 Oct;265(Pt A):114999. doi: 10.1016/j.envpol.2020.114999. Epub 2020 Jun 13.
Overweight and obesity have become a global epidemic and concern, and contributed to at least 4.0 million deaths each year worldwide. However, current evidence regarding the impact of air pollution on body weight status remains inconsistent. We therefore conducted a systematic review and meta-analysis to evaluate the effect of long-term exposure to ambient air pollutants on body weight status in adults. Three databases were searched up to Dec 31, 2019 for articles investigating the association of gaseous (sulfur dioxide, nitrogen dioxide, ozone) and particulate (diameter ≤ 10 μm or ≤ 2.5 μm) air pollutants with body weight status. Random effect models were used to estimate the pooled odds ratios (ORs), regression coefficients (β) and their 95% confidence intervals (95% CIs) associated with air pollution. Among twelve studies that were eligible in the systematic review, ten were used to estimate the pooled effect size, and most of them were cross-sectional studies. We identified that ambient air pollution had adverse effects on body weight status. For example, elevated PM and O were associated with higher level of body mass index, with the pooled β (95% CIs) of 0.34 (0.30-0.38) and 0.21 (0.17-0.24) per 10 μg/m increment, respectively. In addition, increased NO, SO and O were associated with higher risk of having overweight/obesity, with the corresponding pooled OR (95% CI) of 1.13 (1.01-1.26), 1.04 (1.01-1.06) and 1.07 (1.02-1.13) per 10 μg/m increment. Overall, air pollution is a potential risk factor for body weight status in adults, and more high-quality studies, especially prospective studies from severely polluted regions, are warranted for comprehensive understanding of its health effects.
超重和肥胖已成为全球性的流行和关注点，全球每年至少有 400 万人因此死亡。然而，目前关于空气污染对体重状况影响的证据仍然不一致。因此，我们进行了一项系统评价和荟萃分析，以评估长期暴露于环境空气污染物对成年人体重状况的影响。我们在三个数据库中搜索了截至 2019 年 12 月 31 日的文章，以调查气态（二氧化硫、二氧化氮、臭氧）和颗粒（直径≤10μm 或≤2.5μm）空气污染物与体重状况之间的关联。我们使用随机效应模型来估计与空气污染相关的汇总比值比（OR）、回归系数（β）及其 95%置信区间（95%CI）。在系统评价中符合条件的 12 项研究中，有 10 项用于估计汇总效应大小，其中大多数是横断面研究。我们发现，环境空气污染对体重状况有不良影响。例如，PM 和 O 的浓度升高与体重指数水平升高有关，汇总β（95%CI）分别为 0.34（0.30-0.38）和 0.21（0.17-0.24）/每 10μg/m 增加。此外，NO、SO 和 O 的浓度升高与超重/肥胖的风险增加有关，相应的汇总 OR（95%CI）分别为 1.13（1.01-1.26）、1.04（1.01-1.06）和 1.07（1.02-1.13）/每 10μg/m 增加。总的来说，空气污染是成年人体重状况的一个潜在危险因素，需要更多高质量的研究，特别是来自污染严重地区的前瞻性研究，以全面了解其对健康的影响。
