State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022 China.
University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
ACS Appl Mater Interfaces. 2020 Sep 16;12(37):41071-41078. doi: 10.1021/acsami.0c10531. Epub 2020 Sep 2.
As an important noninvasive tumor treatment method, phototherapy has drawn extensive research interest. However, the requirements of separate excitation wavelengths, high degree of electron-hole recombination, and low reactive oxygen species (ROS) production capability are still the major barriers. This work reports the construction of a novel nanoplatform: design and synthesis of an aza-BODIPY (AB) probe-decorated mesoporous black titanium dioxide (TiO) (MT) nanoparticles (NPs) for enhanced photodynamic therapy and photothermal therapy under single-wavelength near-infrared (NIR) laser irradiation for the first time. AB probe-decorated MT NPs (abbreviated as MTAB) were synthesized through the Al reduction of mesoporous anatase TiO NPs and subsequent adsorption of the AB probe. The mesoporous structure of MT ensured AB loading capacity and avoided the complicated modification and synthesis processes. Heterogeneous MTAB, which possessed staggered energy levels, were assessed for their capability for effective separation of photogenerated electrons and holes for the first time. Upon NIR laser light irradiation, MTAB exhibited sufficient ROS generation, resulting in distinct tumor cell killing and tumor tissue elimination. This unique heterogeneous nanoplatform with staggered energy levels provides a new strategy to enhance ROS generation and improve the therapeutic efficacy.
作为一种重要的非侵入性肿瘤治疗方法，光疗引起了广泛的研究兴趣。然而，单独的激发波长、高电子-空穴复合度和低活性氧（ROS）产生能力的要求仍然是主要障碍。本工作首次报道了一种新型纳米平台的构建：设计并合成了一种氮杂-BODIPY（AB）探针修饰的介孔黑二氧化钛（TiO）（MT）纳米粒子（NPs），用于在单波长近红外（NIR）激光照射下增强光动力疗法和光热疗法。AB 探针修饰的 MT NPs（缩写为 MTAB）是通过介孔锐钛矿 TiO NPs 的 Al 还原和随后吸附 AB 探针合成的。MT 的介孔结构保证了 AB 的负载能力，并避免了复杂的修饰和合成过程。首次评估了具有交错能级的异质 MTAB 有效分离光生电子和空穴的能力。在近红外激光照射下，MTAB 表现出足够的 ROS 生成，导致明显的肿瘤细胞杀伤和肿瘤组织消除。这种具有交错能级的独特异质纳米平台提供了一种新的策略来增强 ROS 的产生并提高治疗效果。
