Department of Gastroenterology and Hepatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Department of Internal Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.
Acta Radiol. 2021 Jul;62(7):858-866. doi: 10.1177/0284185120946713. Epub 2020 Aug 17.
Gastrointestinal (GI) symptoms are common in patients with ulcerative colitis (UC), even when the disease is in remission, possibly due to abnormalities in GI motility. Small bowel motility can be assessed globally and in specific intestinal regions during magnetic resonance enterography (MRE) using a displacement mapping technique.
To investigate whether small bowel motility in MRE differs between patients with UC and controls, and if altered motility correlates with GI symptoms.
In 2016-2018, patients who were admitted for MRE, regardless of clinical indication, were consecutively invited to the study. Healthy volunteers were recruited. The participants completed a questionnaire regarding GI symptoms and relevant clinical data were reviewed in the medical records. The dynamic imaging series obtained during MRE were sent for motility mapping and a motility index (MI) was calculated in jejunum, ileum and terminal ileum in all participants.
In total, 224 patients and healthy volunteers were enrolled in the study. Fifteen were diagnosed with UC and 22 were considered healthy controls. In UC, the prevalence of GI symptoms was higher than in controls ( < 0.001), both in remission and in active disease. There was no correlation between GI symptoms and small bowel motility in UC. Jejunal motility was lower in UC than in controls ( = 0.049).
Jejunal motility is decreased in UC compared with healthy controls, but there is no relationship between small bowel motility and GI symptoms in UC.
胃肠道（GI）症状在溃疡性结肠炎（UC）患者中很常见，即使在疾病缓解期也是如此，这可能是由于 GI 运动异常所致。在磁共振肠造影术（MRE）中，可以使用位移映射技术对小肠运动进行整体评估和特定肠段评估。
研究 MRE 中小肠运动在 UC 患者和对照组之间是否存在差异，以及运动改变是否与 GI 症状相关。
2016-2018 年间，连续邀请因 MRE 入院的患者（无论临床指征如何）参加研究。同时招募健康志愿者。参与者完成了一份关于 GI 症状的问卷，并且在病历中回顾了相关的临床数据。将在 MRE 期间获得的动态成像系列发送进行运动图绘制，并在所有参与者的空肠、回肠和末端回肠中计算运动指数（MI）。
共有 224 名患者和健康志愿者参加了这项研究。其中 15 名被诊断为 UC，22 名被认为是健康对照组。在 UC 中，GI 症状的患病率高于对照组（<0.001），无论是在缓解期还是在活动期。UC 中 GI 症状与小肠运动之间没有相关性。UC 患者的空肠运动低于对照组（=0.049）。
与健康对照组相比，UC 患者的空肠运动减少，但 UC 中小肠运动与 GI 症状之间没有关系。
