Clifford Kalin M, Feighner Lydia, McCarrell Jamie L, Hong Peter
Sr Care Pharm. 2020 Sep 1;35(9):394-397. doi: 10.4140/TCP.n.2020.394.
Oseltamivir is an effective agent for both the treatment and prevention of influenza, and its use is increasing. The package insert indicates that delirium and delirium-like events have been reported with the use of oseltamivir during postmarketing surveillance. The reports of neuropsychiatric events associated with oseltamivir are mainly in younger patients. To our knowledge, this is the first reported case of oseltamivirassociated neuropsychiatric events occurring with oseltamivir prophylaxis in an older adult.
A 74-year-old male with a history of mild neurocognitive disorder was given oseltamivir prophylaxis in the setting of an influenza outbreak during his rehabilitation facility stay and developed newfound psychiatric symptoms after administration of oseltamivir for influenza prophylaxis because of institutional outbreak. The patient recovered completely after cessation of oseltamivir.
We hope that our case report highlights the importance of careful consideration when prescribing oseltamivir prophylaxis in older people with or without previous history of neurocognitive disorder.
奥司他韦是一种治疗和预防流感的有效药物，其使用正在增加。药品说明书表明，在上市后监测期间，已有使用奥司他韦后出现谵妄和类谵妄事件的报告。与奥司他韦相关的神经精神事件报告主要发生在年轻患者中。据我们所知，这是首例在老年患者中使用奥司他韦预防流感时发生奥司他韦相关神经精神事件的报告。
一名74岁男性，有轻度神经认知障碍病史，在康复机构住院期间，因流感暴发接受奥司他韦预防用药，在使用奥司他韦预防流感后出现了新的精神症状。停用奥司他韦后，患者完全康复。
我们希望我们的病例报告能凸显在给有或没有神经认知障碍病史的老年人开奥司他韦预防用药时，仔细考虑的重要性。
