Polinsky R J, Taylor I L, Weise V, Kopin I J
Clinical Neuropharmacology Section, N.I.N.C.D.S., Bethesda, MD 20892.
J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):67-71. doi: 10.1136/jnnp.51.1.67.
High basal gastrin levels in pure autonomic failure could result from peripheral vagus nerve involvement, whereas the increased response during hypoglycaemia may reflect adrenergic supersensitivity. A reduced gastrin increment in multiple system atrophy was found following insulin-hypoglycaemia and is consistent with decreased gastrin release secondary to diminished central sympathetic nervous system activation in the absence of peripheral denervation supersensitivity.
单纯自主神经功能衰竭时基础胃泌素水平升高可能源于外周迷走神经受累,而低血糖期间反应增强可能反映了肾上腺素能超敏反应。在胰岛素低血糖后发现多系统萎缩患者胃泌素增量减少,这与在无外周去神经超敏反应的情况下,由于中枢交感神经系统激活减弱导致胃泌素释放减少相一致。