Makover D, Freundlich B, Zurier R B
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
J Rheumatol. 1988 Jan;15(1):117-9.
Cyclosporine A (CyA) is being increasingly used as an immunosuppressive agent to treat various autoimmune diseases. A patient with systemic lupus erythematosus (SLE) receiving CyA after renal transplantation suffered a disease relapse associated with high serum CyA levels. Lowering of the CyA dose and the start of steroids resulted in a rapid improvement in her condition. Trials evaluating CyA for SLE should proceed with caution since under certain circumstances this drug may exacerbate disease activity.
环孢素A（CyA）作为一种免疫抑制剂越来越多地用于治疗各种自身免疫性疾病。一名系统性红斑狼疮（SLE）患者在肾移植后接受CyA治疗，出现了与血清CyA水平升高相关的疾病复发。降低CyA剂量并开始使用类固醇后，她的病情迅速改善。评估CyA治疗SLE的试验应谨慎进行，因为在某些情况下，这种药物可能会加剧疾病活动。
