Ophthalmology Department, Lazergoz Hospital, Kayseri, Turkey.
Clin Exp Optom. 2021 Mar;104(2):172-177. doi: 10.1111/cxo.13127.
Understanding the reduction in clarity of the ocular media in patients with chronic obstructive pulmonary disease (COPD) will aid interpretation of ocular examinations and refractive assessments in patients with this condition.
To investigate corneal and lens densitometry measurements of patients with COPD and to compare the results obtained with those in healthy adults.
This prospective cross-sectional study included 25 newly diagnosed COPD patients (COPD group) and 35 healthy subjects (control group). The COPD patients were excluded if they ever had any recorded systemic or inhaler steroid therapy. After recording demographic and clinical characteristics, eligible study subjects underwent a through ophthalmic evaluation which included measurement of refractive errors using the same automatic refractor-keratometer device, best-corrected visual acuity determination using a Snellen chart, measurement of intraocular pressure using a pneumotonometer, slitlamp biomicroscopy and fundus examination. After general ophthalmic examination, the Pentacam HR imaging system was used to evaluate corneal and lens densitometry measurements of the groups.
There were no statistically significant differences in the ages and genders of the participants between the two groups (p > 0.05). Additionally, the mean values of intraocular pressure, refractive error and body mass index as well as smoking status were similar between the groups (p > 0.05, for all). The mean corneal densitometry values were also similar in all the concentric zones and layers in the eyes of the patients with COPD and controls (p > 0.05, for all). However, the mean values of zones 1, 2 and 3, and average lens densitometry measurements of the COPD group, were statistically significantly higher compared to control subjects (p < 0.05, for all).
Lens clarity of patients with COPD was significantly decreased while corneal densitometry measurements were not significantly affected.
了解慢性阻塞性肺疾病（COPD）患者眼内介质清晰度的降低，将有助于解释该疾病患者的眼部检查和屈光评估结果。
研究 COPD 患者的角膜和晶状体密度测量值，并将结果与健康成年人进行比较。
这项前瞻性的横断面研究纳入了 25 例新诊断的 COPD 患者（COPD 组）和 35 例健康受试者（对照组）。如果 COPD 患者曾经有任何记录的全身或吸入性类固醇治疗，则将其排除在外。记录完人口统计学和临床特征后，符合条件的研究对象接受了全面的眼科评估，包括使用相同的自动折射角膜仪设备测量屈光不正、使用 Snellen 图表确定最佳矫正视力、使用眼压计测量眼压、裂隙灯生物显微镜检查和眼底检查。一般眼科检查后，使用 Pentacam HR 成像系统评估两组的角膜和晶状体密度测量值。
两组患者的年龄和性别无统计学差异（p>0.05）。此外，两组的眼压、屈光不正和体重指数以及吸烟状况的平均值也相似（p>0.05，均为 P>0.05）。COPD 患者和对照组的所有同心区和眼层的平均角膜密度值也相似（p>0.05，均为 P>0.05）。然而，COPD 组的 1、2 和 3 区的平均值和平均晶状体密度测量值均明显高于对照组（p<0.05，均为 P<0.05）。
COPD 患者的晶状体清晰度明显下降，而角膜密度测量值无明显变化。
