Du Toit D F, Heydenrych J J, Smit B, Louw G, Zuurmond T, Els D, Weideman A, Wolfe-Coote S, Du Toit L, Davids H
Department of Surgery, University of Stellenbosch Medical School, Tygerberg, South Africa.
J Surg Oncol. 1988 Mar;37(3):207-12. doi: 10.1002/jso.2930370316.
This study assessed the early postoperative pancreatic endocrine function after intraperitoneal segmental hetero- and ortho-topic pancreatic allotransplantation in hemipancreatectomized, nonimmunesuppressed chacma baboons. Hemipancreatectomized animals remained normoglycaemic but rendered significantly reduced K values and insulin release during IVGTT, findings consistent with major pancreatic resection. Segmental hetero- or ortho-topic pancreatic transplantation did not improve reduced K values and hypoinsulinaemia following hemipancreatectomy although orthotopically sited grafts rendered the best glucose tolerance test curves. Glucagon output during IVGTT remained the same in both transplant models. It is concluded that the postoperative hormonal response was similar in both orthotopic and heterotopic transplant recipients, which indicates that drainage of graft venous effluent into the portal circulation has no advantage over systemic insulin drainage as reflected in this "diabetic" model.
本研究评估了半胰切除、未免疫抑制的南非大狒狒在接受腹腔节段性异位和原位胰腺同种异体移植后的早期术后胰腺内分泌功能。半胰切除的动物血糖仍保持正常，但在静脉葡萄糖耐量试验（IVGTT）期间K值显著降低且胰岛素释放减少，这些结果与主要的胰腺切除术一致。节段性异位或原位胰腺移植并未改善半胰切除术后降低的K值和低胰岛素血症，尽管原位移植的移植物产生了最佳的葡萄糖耐量试验曲线。在两种移植模型中，IVGTT期间的胰高血糖素输出保持不变。得出的结论是，原位和异位移植受者术后的激素反应相似，这表明在这个“糖尿病”模型中，移植静脉流出物引流至门静脉循环并不比全身胰岛素引流更具优势。
