Kyriakopoulos Chris, Gupta Vikas
University Hospital of Ioannina
Wellness Psychiatry P.C
The effects of many drugs are altered in renal impairment, particularly when a drug is renally cleared. Drug doses should be altered based on the predicted reduction in the clearance of the drug. Patient factors, such as the degree of renal disease and patient size, also influence the decision to adjust drug doses. In addition, drug factors, including the drug excretion and the therapeutic index, must be considered when adjusting doses. Accurate estimation of renal function is crucial for determining appropriate doses of renally excreted drugs.
许多药物的作用在肾功能损害时会发生改变，尤其是当一种药物经肾脏清除时。应根据预测的药物清除率降低情况调整药物剂量。患者因素，如肾脏疾病的程度和患者体型，也会影响调整药物剂量的决定。此外，在调整剂量时必须考虑药物因素，包括药物排泄和治疗指数。准确估计肾功能对于确定经肾脏排泄药物的合适剂量至关重要。
