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尘螨过敏

Dust Mite Allergy

作者信息

Aggarwal Pearl, Senthilkumaran S

机构信息

University Hospitals

Department of Emergency Medicine and Critical Care, Manian Medical Centre, Erode, India

Abstract

Dust mite allergy is an allergic condition that occurs as a reaction to the dust mite allergens that commonly live in household dust. It is also known as house dust allergy. It is sensitization and an allergic reaction to the droppings of the dust mites. The droppings are an indoor aeroallergen, which on inhalation triggers the allergic reaction. The prevalence of atopic diseases like allergic rhinitis and asthma with house dust mite being the allergen has been increasing. House dust allergy was first identified as an allergen around 1920. In 1967, Voorhorst et al. identified   as the causative allergen for house dust allergy. The first mite allergen identified was the cysteine protease allergen I, or Der p 1 in 1980, followed by Der p 2, and homologous 1 and 2. The house dust mite (HDM or DM) is a predominant source of indoor aeroallergens. Some of the allergic diseases that have been associated with the HDM are allergic rhinoconjunctivitis, allergic asthma, and atopic eczema. The best treatment strategy for allergic rhinitis consists of allergen avoidance first, in junction with pharmacotherapy and allergen immunotherapy (AIT). The appropriate pharmacotherapy consists of antihistamines, leukotriene receptor antagonists, and inhaled or intranasal corticosteroids (ICS). All these treatments are effective and safe, but unfortunately, haven't proved to change the course of HDM related allergic diseases.

摘要

尘螨过敏是一种过敏病症,是对通常存在于家庭灰尘中的尘螨过敏原产生的反应。它也被称为屋尘过敏。它是对尘螨粪便的致敏和过敏反应。这些粪便属于室内空气过敏原,吸入后会引发过敏反应。以屋尘螨作为过敏原的过敏性鼻炎和哮喘等特应性疾病的患病率一直在上升。屋尘过敏在1920年左右首次被确定为一种过敏原。1967年,福霍斯特等人确定 为屋尘过敏的致病过敏原。1980年确定的首个螨过敏原是半胱氨酸蛋白酶过敏原I,即Der p 1,随后是Der p 2以及同源物1和2。屋尘螨是室内空气过敏原的主要来源。一些与屋尘螨相关的过敏性疾病包括过敏性鼻结膜炎、过敏性哮喘和特应性皮炎。过敏性鼻炎的最佳治疗策略首先是避免接触过敏原,同时结合药物治疗和过敏原免疫疗法(AIT)。合适的药物治疗包括抗组胺药、白三烯受体拮抗剂以及吸入性或鼻内用皮质类固醇(ICS)。所有这些治疗方法都是有效且安全的,但不幸的是,尚未证明能改变与屋尘螨相关的过敏性疾病的病程。

相似文献

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Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD).IgE介导的过敏性疾病中变应原特异性免疫治疗指南:德国变态反应学与临床免疫学会(DGAKI)、儿科变态反应与环境医学学会(GPA)、德国变态反应科医生医学协会(AeDA)、奥地利变态反应与免疫学会(ÖGAI)、瑞士变态反应与免疫学会(SGAI)、德国皮肤病学会(DDG)、德国耳鼻咽喉头颈外科学会(DGHNO-KHC)、德国儿科学与青少年医学学会(DGKJ)、儿科肺病学会(GPP)、德国呼吸学会(DGP)、德国耳鼻喉外科医生协会(BV-HNO)、儿科医生与青年医生专业联合会(BVKJ)、肺科医生联邦协会(BDP)以及德国皮肤科医生协会(BVDD)的S2k指南
Allergo J Int. 2014;23(8):282-319. doi: 10.1007/s40629-014-0032-2.

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