Ahmed Intisar, Yandrapalli Srikanth
Aga Khan University Pakistan
New York Medical College/Westchester Medical Center
The mainstay for the treatment of multi-vessel severe coronary artery disease is coronary artery bypass graft (CABG) surgery. Various grafts and conduits have been used and were studied to optimize surgical outcomes. The internal mammary artery (IMA) is the gold-standard conduit and associated with significant improvement in short and long-term outcomes and survival of patients undergoing CABG surgery. The saphenous vein graft (SVG), also commonly used in CABG procedure, is prone to early atherosclerotic changes that lead to obstruction. Therefore it is considered inferior to the IMA conduit in terms of long-term patency rates. In comparison to SVGs, the long-term patency rate of IMA bypass conduits is very high, and around 90% of grafts remain free of significant stenosis at ten years. Loop . published 10-year survival of patients who received an IMA graft to the left anterior descending coronary artery with or without one or more vein grafts versus patients who received only SVGs, which showed that the survival was higher with an IMA graft (93.4%) versus SVG (88.0%) for those with the one-vessel disease, 90.0% versus 79.5% for two-vessel disease, and 82.6% versus 71.0% (P<0.0001) for those with three-vessel disease. Since then, the IMA has become the preferred choice for grafting the left anterior descending coronary artery in CABG. Specific physiological, anatomic, and hemodynamic characteristics of IMA graft make it a suitable conduit and less prone to early atherosclerotic changes. We will discuss the anatomy of IMA, the surgical technique of IMA grafting, its complications, and clinical significance.
多支严重冠状动脉疾病的主要治疗方法是冠状动脉旁路移植术(CABG)。人们使用并研究了各种移植物和管道以优化手术效果。乳内动脉(IMA)是金标准管道,与接受CABG手术患者的短期和长期效果及生存率的显著改善相关。大隐静脉移植物(SVG)也常用于CABG手术,但其易于发生早期动脉粥样硬化改变而导致阻塞。因此,就长期通畅率而言,它被认为不如IMA管道。与SVG相比,IMA旁路管道的长期通畅率非常高,约90%的移植物在十年时仍无明显狭窄。Loop……发表了接受左前降支冠状动脉IMA移植物伴或不伴一支或多支静脉移植物的患者与仅接受SVG的患者的10年生存率,结果显示,单支血管疾病患者中,IMA移植物组生存率为93.4%,高于SVG组的88.0%;双支血管疾病患者中,分别为90.0%和79.5%;三支血管疾病患者中,分别为82.6%和71.0%(P<0.0001)。从那时起,IMA已成为CABG中左前降支冠状动脉移植的首选。IMA移植物的特定生理、解剖和血流动力学特征使其成为合适的管道,且不易发生早期动脉粥样硬化改变。我们将讨论IMA的解剖结构、IMA移植的手术技术、其并发症及临床意义。