Departments of Neurology.
Infectious Diseases, Brugmann Hospital, Brussels, Belgium.
Alzheimer Dis Assoc Disord. 2021;35(3):269-270. doi: 10.1097/WAD.0000000000000405.
We describe a case of dementia with Lewy bodies immediately following encephalitis due to West Nile virus (WNV). The patient had rapid eye movement-sleep behavior disorder and constipation before the onset of encephalitis, which suggests that he would have ultimately developed dementia with Lewy bodies even without WNV infection. Our case illustrates the interactions between α-synuclein and WNV, as observed in mouse models, wherein synuclein expression augments after WNV infection and protects neurons against the virus.
我们描述了一例西尼罗河病毒（WNV）引起的脑炎后立即出现的路易体痴呆病例。该患者在脑炎发作前出现快速眼动睡眠行为障碍和便秘，这表明即使没有 WNV 感染，他最终也会发展为路易体痴呆。我们的病例说明了α-突触核蛋白和 WNV 之间的相互作用，正如在小鼠模型中观察到的那样，WNV 感染后突触核蛋白表达增加，并保护神经元免受病毒侵害。
