Department of Head & Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, PR China.
Department of Ultrasound, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, PR China.
Future Oncol. 2020 Nov;16(33):2735-2746. doi: 10.2217/fon-2020-0213. Epub 2020 Aug 19.
Thyroglobulin washout of fine needle aspiration (FNA-Tg) has proved to be useful in detecting lymph node metastases from papillary thyroid cancer; however, the influences of thyroid gland, Hashimoto thyroiditis, serum thyroglobulin (Tg) and anti-TG antibody on the diagnostic performance of FNA-Tg are controversial. We retrospectively collected the FNA-Tg results of 176 preoperative or postoperative patients (356 lymph nodes) who finally were diagnosed with papillary thyroid cancer. The diagnostic abilities of FNA-Tg were evaluated and compared under different circumstances. The diagnostic performance of FNA-Tg was uninfluenced irrespective of the status of thyroid gland or serum anti-TG antibody. However, high serum Tg was positively correlated with FNA-Tg (Exp(B) = 1.57; 95% CI: 1.209-2.309; p = 0.001). FNA-Tg was an excellent diagnostic tool, but it should be interpreted with caution only if serum Tg is higher than 10 ng/ml.
细针穿刺洗脱液甲状腺球蛋白（FNA-Tg）已被证明可用于检测甲状腺乳头状癌的淋巴结转移；然而，甲状腺、桥本甲状腺炎、血清甲状腺球蛋白（Tg）和抗 TG 抗体对 FNA-Tg 诊断性能的影响存在争议。我们回顾性收集了最终诊断为甲状腺乳头状癌的 176 例术前或术后患者（356 个淋巴结）的 FNA-Tg 结果。评估并比较了不同情况下 FNA-Tg 的诊断能力。FNA-Tg 的诊断性能不受甲状腺状态或血清抗 TG 抗体的影响。然而，高血清 Tg 与 FNA-Tg 呈正相关（Exp(B) = 1.57；95%CI：1.209-2.309；p = 0.001）。FNA-Tg 是一种优秀的诊断工具，但只有当血清 Tg 高于 10ng/ml 时，才应谨慎解读。
