半乳糖凝集素-1与2型糖尿病呈负相关，独立于肥胖因素——一项斯堪的纳维亚心血管疾病队列研究（SCAPIS）的初步研究
Galectin-1 is inversely associated with type 2 diabetes independently of obesity - A SCAPIS pilot study.
作者信息
Fryk Emanuel, Strindberg Lena, Lundqvist Annika, Sandstedt Mikael, Bergfeldt Lennart, Mattsson Hultén Lillemor, Bergström Göran, Jansson Per-Anders
机构信息
Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg and the Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Clinical Chemistry, Sahlgrenska University Hospital and Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
出版信息
Metabol Open. 2019 Sep 5;4:100017. doi: 10.1016/j.metop.2019.100017. eCollection 2019 Dec.
OBJECTIVES
Galectin-1 is a recently discovered adipokine that increases with obesity and increased energy intake in adipose tissue. Our aim was to assess whether serum galectin-1 is associated with type 2 diabetes (T2D) and other parameters of the metabolic syndrome independently of body mass index (BMI) in a cohort from the general population.
METHODS
In this cross-sectional population-based cohort study from the western part of Sweden, we investigated associations between serum galectin-1, clinical characteristics and inflammatory markers in 989 women and men aged 50-65 years [part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort].
RESULTS
We showed in linear models that serum galectin-1 was independently and: (1) inversely associated with T2D (p < 0.05) and glucose (p < 0.05); and (2) positively associated with age (p < 0.01), sex (p < 0.01), BMI (p < 0.01), insulin (p < 0.01) and C-reactive protein (p < 0.01). Furthermore, galectin-1 demonstrated univariate correlations with triglycerides (r = 0.20, p < 0.01), homeostasis model assessment for insulin resistance (r = 0.24, p < 0.01), tumor necrosis factor-α (r = 0.24, p < 0.01), interleukin-6 (IL-6; r = 0.20, p < 0.01) and HbA1c (r = 0.14, p < 0.01).
CONCLUSION
In a cross-sectional study of a middle-aged population, we showed that serum galectin-1 is: (1) inversely associated with T2D independently of BMI; and (2) independently associated with other markers of the metabolic syndrome These results warrant prospective and functional studies on the role of galectin-1 in T2D.
目的
半乳糖凝集素-1是一种最近发现的脂肪因子，其水平会随着肥胖以及脂肪组织中能量摄入的增加而升高。我们的目的是评估在一个来自普通人群的队列中，血清半乳糖凝集素-1是否独立于体重指数（BMI）与2型糖尿病（T2D）及代谢综合征的其他参数相关。
方法
在这项基于瑞典西部人群的横断面队列研究中，我们调查了989名年龄在50至65岁之间的男性和女性（瑞典心肺生物图像研究（SCAPIS）试点队列的一部分）血清半乳糖凝集素-1、临床特征和炎症标志物之间的关联。
结果
我们在线性模型中发现，血清半乳糖凝集素-1独立地且：（1）与T2D呈负相关（p<0.05）以及与血糖呈负相关（p<0.05）；（2）与年龄呈正相关（p<0.01）、与性别呈正相关（p<0.01）、与BMI呈正相关（p<0.01）、与胰岛素呈正相关（p<0.01）以及与C反应蛋白呈正相关（p<0.01）。此外，半乳糖凝集素-1与甘油三酯呈单变量相关性（r = 0.20，p<0.01）、与胰岛素抵抗的稳态模型评估呈单变量相关性（r = 0.24，p<0.01）、与肿瘤坏死因子-α呈单变量相关性（r = 0.24，p<0.01）、与白细胞介素-6（IL-6；r = 0.20，p<0.01）以及与糖化血红蛋白（r = 0.14，p<0.01）呈单变量相关性。
结论
在一项针对中年人群的横断面研究中，我们发现血清半乳糖凝集素-1：（1）独立于BMI与T2D呈负相关；（2）独立于BMI与代谢综合征的其他标志物相关。这些结果为关于半乳糖凝集素-1在T2D中的作用的前瞻性和功能性研究提供了依据。
Zotero 插件