代谢紊乱患者心脏自主神经功能和舒张功能的亚临床下降：HSCAA研究
Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study.
作者信息
Morimoto Akiko, Kadoya Manabu, Kakutani-Hatayama Miki, Kosaka-Hamamoto Kae, Miyoshi Akio, Shoji Takuhito, Goda Akiko, Asakura Masanori, Koyama Hidenori
机构信息
Division of Diabetes, Endocrinology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Division of Cardiovascular and Renal Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
出版信息
Metabol Open. 2020 Jan 22;5:100025. doi: 10.1016/j.metop.2020.100025. eCollection 2020 Mar.
Heart failure due to decreased diastolic function, HFpEF, is a growing health concern with rising prevalence. We examined subclinical cardiac autonomic and diastolic functions in 605 patients with metabolic diseases classified as pre-heart failure. Presence of glucose intolerance or diabetes, or visceral adiposity was significantly associated with reduced cardiac autonomic and diastolic functions. Higher autonomic functions were significantly associated with a parameter of better cardiac diastolic function (E/A) (SDNN: r = 0.306, p < 0.01; HF: r = 0.341, p < 0.01), with the association independent of diabetes, body mass index, visceral adiposity and insulin resistance index. Thus, reduced autonomic function may be a potential predictor for decreased cardiac diastolic functions in metabolic disorders.
舒张功能降低所致的心衰（HFpEF）是一个日益受到关注的健康问题，其患病率不断上升。我们对605例被归类为心力衰竭前期的代谢疾病患者的亚临床心脏自主神经功能和舒张功能进行了检查。葡萄糖耐量异常或糖尿病，或内脏肥胖的存在与心脏自主神经功能和舒张功能降低显著相关。较高的自主神经功能与较好的心脏舒张功能参数（E/A）显著相关（SDNN：r = 0.306，p < 0.01；HF：r = 0.341，p < 0.01），这种关联独立于糖尿病、体重指数、内脏肥胖和胰岛素抵抗指数。因此，自主神经功能降低可能是代谢紊乱中心脏舒张功能降低的一个潜在预测指标。
Zotero 插件