调控人类端粒酶 RNA 的生物发生和定位。
Regulation of human telomerase RNA biogenesis and localization.
机构信息
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Jewish General Hospital, Lady Davis Institute, Montreal, Quebec, Canada.
出版信息
RNA Biol. 2021 Mar;18(3):305-315. doi: 10.1080/15476286.2020.1809196. Epub 2020 Sep 2.
Abstract
Maintenance of telomeres is essential for genome integrity and replicative capacity in eukaryotic cells. Telomerase, the ribonucleoprotein complex that catalyses telomere synthesis is minimally composed of a reverse transcriptase and an RNA component. The sequence and structural domains of human telomerase RNA (hTR) have been extensively characterized, while the regulation of hTR transcription, maturation, and localization, is not fully understood. Here, we provide an up-to-date review of hTR, with an emphasis on current breakthroughs uncovering the mechanisms of hTR maturation and localization.
摘要
端粒的维持对于真核细胞的基因组完整性和复制能力至关重要。端粒酶是一种催化端粒合成的核蛋白复合物，其最小组成部分是逆转录酶和 RNA 成分。人类端粒酶 RNA（hTR）的序列和结构域已得到广泛描述，而 hTR 转录、成熟和定位的调控机制尚不完全清楚。本文重点介绍 hTR 成熟和定位机制方面的最新研究进展，对 hTR 进行了全面综述。
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