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Regulation of human telomerase RNA biogenesis and localization.调控人类端粒酶 RNA 的生物发生和定位。
RNA Biol. 2021 Mar;18(3):305-315. doi: 10.1080/15476286.2020.1809196. Epub 2020 Sep 2.
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Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal.人类端粒酶RNA与盒式H/ACA小核仁RNA共享一个共同的卡哈尔体特异性定位信号。
J Cell Biol. 2004 Mar 1;164(5):647-52. doi: 10.1083/jcb.200310138. Epub 2004 Feb 23.
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Human telomerase reverse transcriptase binds to a pre-organized hTR in vivo exposing its template.人类端粒酶逆转录酶在体内与预先组装好的人端粒酶RNA结合，从而暴露其模板。
Nucleic Acids Res. 2016 Jan 8;44(1):413-25. doi: 10.1093/nar/gkv1065. Epub 2015 Oct 19.
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Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation.人类 TGS1 超甲基化酶缺失促进端粒酶 RNA 和端粒延长。
Cell Rep. 2020 Feb 4;30(5):1358-1372.e5. doi: 10.1016/j.celrep.2020.01.004.
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Human telomerase RNA-protein interactions.人类端粒酶RNA与蛋白质的相互作用。
Nucleic Acids Res. 2001 Aug 15;29(16):3385-93. doi: 10.1093/nar/29.16.3385.
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Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation.人类端粒酶RNA在卡哈尔体中的积累有助于端粒酶募集到端粒并延长端粒。
Mol Cell. 2007 Sep 21;27(6):882-9. doi: 10.1016/j.molcel.2007.07.020.
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Analysis of a long-range interaction between conserved domains of human telomerase RNA.人端粒酶RNA保守结构域之间远程相互作用的分析
RNA. 2004 Jan;10(1):139-47. doi: 10.1261/rna.5118104.
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Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.人端粒酶全酶体内组装时亚基相互作用的特异性和化学计量。
Mol Cell Biol. 2010 Jun;30(11):2775-86. doi: 10.1128/MCB.00151-10. Epub 2010 Mar 29.
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Evolutionary perspectives of telomerase RNA structure and function.端粒酶RNA结构与功能的进化观点
RNA Biol. 2016 Aug 2;13(8):720-32. doi: 10.1080/15476286.2016.1205768. Epub 2016 Jun 30.
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Structural and functional characterization of human telomerase RNA processing and cajal body localization signals.人类端粒酶RNA加工及卡哈尔体定位信号的结构与功能表征
Mol Cell. 2007 Sep 21;27(6):869-81. doi: 10.1016/j.molcel.2007.07.017.
引用本文的文献
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NHP2 and PRPF4 are hub genes associated with the prognosis of colorectal cancer.NHP2和PRPF4是与结直肠癌预后相关的枢纽基因。
BMC Cancer. 2025 Jul 1;25(1):1088. doi: 10.1186/s12885-025-14431-2.
2
Biogenesis and Regulation of Telomerase during Development and Cancer.发育与癌症过程中端粒酶的生物发生及调控
Cold Spring Harb Perspect Biol. 2025 Apr 10. doi: 10.1101/cshperspect.a041692.
3
Trafficking of the telomerase RNA using a novel genetic approach.利用一种新的基因方法对端粒酶RNA进行运输。
PLoS One. 2025 Apr 2;20(4):e0313178. doi: 10.1371/journal.pone.0313178. eCollection 2025.
4
Telomere function and regulation from mouse models to human ageing and disease.从小鼠模型到人类衰老与疾病的端粒功能及调控
Nat Rev Mol Cell Biol. 2025 Apr;26(4):297-313. doi: 10.1038/s41580-024-00800-5. Epub 2024 Nov 29.
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Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte.Tert通过减轻活性氧诱导的心肌细胞DNA损伤反应促进心肌梗死后的心脏再生修复。
Cell Death Discov. 2024 Aug 26;10(1):381. doi: 10.1038/s41420-024-02135-8.
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LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis.LARP3、LARP7 和 MePCE 参与人类端粒酶 RNA 生物发生的早期阶段。
Nat Commun. 2024 Jul 15;15(1):5955. doi: 10.1038/s41467-024-50422-w.
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The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.端粒酶假尿嘧啶合成酶的C末端延伸是先天性角化不良的突变热点，可调节与端粒酶RNA的相互作用及亚细胞定位。
Hum Mol Genet. 2024 Feb 1;33(4):318-332. doi: 10.1093/hmg/ddad180.
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Post-Transcriptional and Post-Translational Modifications in Telomerase Biogenesis and Recruitment to Telomeres.端粒酶生物发生和招募到端粒的转录后和翻译后修饰。
Int J Mol Sci. 2023 Mar 6;24(5):5027. doi: 10.3390/ijms24055027.
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Proteomic analyses reveal new features of the box H/ACA RNP biogenesis.蛋白质组分析揭示了 box H/ACA RNP 生物发生的新特征。
Nucleic Acids Res. 2023 Apr 24;51(7):3357-3374. doi: 10.1093/nar/gkad129.
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Telomere biology disorders: time for moving towards the clinic?端粒生物学障碍：向临床迈进的时候到了吗？
Trends Mol Med. 2022 Oct;28(10):882-891. doi: 10.1016/j.molmed.2022.08.001. Epub 2022 Sep 1.
本文引用的文献
1
Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.单分子成像揭示端粒酶 RNA 募集-保留模型用于端粒延长。
Mol Cell. 2020 Jul 2;79(1):115-126.e6. doi: 10.1016/j.molcel.2020.05.005. Epub 2020 Jun 3.
2
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.小分子PAPD5抑制剂可恢复患者干细胞中的端粒酶活性。
Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. doi: 10.1016/j.stem.2020.03.016. Epub 2020 Apr 21.
3
Regulation of human telomerase in homeostasis and disease.人类端粒酶在体内平衡和疾病中的调控。
Nat Rev Mol Cell Biol. 2020 Jul;21(7):384-397. doi: 10.1038/s41580-020-0234-z. Epub 2020 Apr 2.
4
A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome.双层靶向机制是人类核外切体进行核 RNA 分拣的基础。
Cell Rep. 2020 Feb 18;30(7):2387-2401.e5. doi: 10.1016/j.celrep.2020.01.068.
5
Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation.人类 TGS1 超甲基化酶缺失促进端粒酶 RNA 和端粒延长。
Cell Rep. 2020 Feb 4;30(5):1358-1372.e5. doi: 10.1016/j.celrep.2020.01.004.
6
HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation.hnRNP F/H 与 hTERC 和端粒酶全酶结合，调节端粒酶功能并促进细胞增殖。
Cell Death Differ. 2020 Jun;27(6):1998-2013. doi: 10.1038/s41418-019-0483-6. Epub 2019 Dec 20.
7
The Nuclear RNA Exosome and Its Cofactors.核 RNA 外切体及其辅助因子。
Adv Exp Med Biol. 2019;1203:113-132. doi: 10.1007/978-3-030-31434-7_4.
8
Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length.Nopp140 介导的端粒酶在 Cajal 体中的集中调节端粒长度。
Mol Biol Cell. 2019 Dec 15;30(26):3136-3150. doi: 10.1091/mbc.E19-08-0429. Epub 2019 Oct 30.
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, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.核 exosome 靶向组件在家族性肺纤维化中发生突变，并且是端粒酶 RNA 成熟所必需的。
Genes Dev. 2019 Oct 1;33(19-20):1381-1396. doi: 10.1101/gad.326785.119. Epub 2019 Sep 5.
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SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.SMUG1 通过端粒酶 RNA 加工促进端粒维持。
Cell Rep. 2019 Aug 13;28(7):1690-1702.e10. doi: 10.1016/j.celrep.2019.07.040.
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