Paç Kısaarslan Ayşenur, Şahin Nihal, Özdemir Çiçek Sümeyra, Gündüz Zübeyde, Poyrazoğlu Hakan, Düşünsel Ruhan
Department of Pediatric Rheumatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Mod Rheumatol. 2021 May;31(3):718-724. doi: 10.1080/14397595.2020.1812809. Epub 2020 Sep 7.
Familial Mediterranean fever (FMF) may present with various concomitant diseases. This study aims to evaluate the clinical characteristics of patients with FMF with Juvenile Spondyloarthropathy (jSpA).
Thirty-two patients diagnosed with FMF/jSpA, sixty-four with FMF, and fifty-four with jSpA were included in this retrospective study. Three patient groups were compared in terms of clinical and laboratory features.
The mean ages of patients in the FMF/jSpA, FMF and jSpA groups were 15.75(11.50-19.83), 15,41(6.83-21.50), and 16(9-22) years, respectively. Chronic arthritis (OR: 0.11, = .049), erythrocyte sedimentation rate values (OR:1.07, = .011), and C-reactive protein values (OR:1,08, : .039) of the patients in remission period were found higher, the international severity scores for FMF (ISSF) before and after colchicine treatment (OR: 1.16, : .021, OR: 2,21, : .012) were higher in the FMF/jSpA group compared to FMF. Plantar fasciitis was more common and HLA-B27 positivity rate was lower in the FMF/jSpA group (OR:0.08, = .024), (OR:4.71, = .002) compared to jSpA. FMF/jSpA patients were divided as previous diagnosed FMF and jSpA.The diagnosis of jSpA was at a younger age( = .002), Juvenile arthritis damage index-articular(p = 0.022) and extraarticular( = .026), and the rate of biologic drug usage( = .015) were higher in the previous jSpA group. The number of FMF attacks before colchicine was lower in the previous jSpA group( = .02).
Our findings suggest that both classical FMF and jSpA findings were lower in patients with FMF/jSpA. Patients who were diagnosed with jSpA at an early age and who had enthesitis and plantar fasciitis should also be evaluated in terms of FMF.
家族性地中海热（FMF）可能伴有多种并发疾病。本研究旨在评估患有青少年脊柱关节炎（jSpA）的FMF患者的临床特征。
本回顾性研究纳入了32例诊断为FMF/jSpA的患者、64例FMF患者和54例jSpA患者。比较了三组患者的临床和实验室特征。
FMF/jSpA组、FMF组和jSpA组患者的平均年龄分别为15.75（11.50 - 19.83）岁、15.41（6.83 - 21.50）岁和16（9 - 22）岁。缓解期患者的慢性关节炎（OR：0.11，P = 0.049）、红细胞沉降率值（OR：1.07，P = 0.011）和C反应蛋白值（OR：1.08，P = 0.039）较高，与FMF组相比，FMF/jSpA组秋水仙碱治疗前后的家族性地中海热国际严重程度评分（ISSF）更高（OR：1.16，P = 0.021，OR：2.21，P = 0.012）。与jSpA组相比，FMF/jSpA组足底筋膜炎更常见，HLA - B27阳性率更低（OR：0.08，P = 0.024），（OR：4.71，P = 0.002）。FMF/jSpA患者分为先前诊断为FMF和jSpA的患者。先前诊断为jSpA的患者中，jSpA的诊断年龄更小（P = 0.002），青少年关节炎损伤指数 - 关节（P = 0.022）和关节外（P = 0.026），生物药物使用率更高（P = 0.015）。先前诊断为jSpA的患者在秋水仙碱治疗前的FMF发作次数更少（P = 0.02）。
我们的研究结果表明，FMF/jSpA患者的经典FMF和jSpA表现均较低。对于早年诊断为jSpA且患有附着点炎和足底筋膜炎的患者，也应从FMF方面进行评估。
