Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing.
Department of Neurosurgery, Xinxiang Central Hospital, Xinxiang, China.
Blood Coagul Fibrinolysis. 2020 Sep;31(6):410-415. doi: 10.1097/MBC.0000000000000933.
: The incidence of antithrombin III (AT III) deficiency is very rare. The most common complication of AT III deficiency is deep venous thrombosis, which causes a low incidence of intracranial sinus thrombosis. We presented a 31-year-old Chinese woman patient who had a family history of AT III deficiency admitted to our hospital. She had a history of pulmonary embolism. She took rivaroxaban for a long time to prevent thrombosis. After giving birth, she stopped taking the medication for half a year and suffered from drug withdrawal symptoms. Four months after drug withdrawal, she suddenly fell into a coma. After diagnosis, it was found to be caused by a subarachnoid hemorrhage. Finally, she was diagnosed with sagittal and transverse sinus thrombosis. After treatment with mechanical thrombectomy, she fully recovered. In sum, we concluded that mechanical thrombectomy was efficient for AT III deficiency and treating thrombosis.
抗凝血酶 III(AT III)缺乏症的发病率非常罕见。AT III 缺乏症最常见的并发症是深静脉血栓形成,导致颅内窦血栓形成的发病率较低。我们报告了一位 31 岁的中国女性患者,她有 AT III 缺乏症家族史,曾因肺栓塞而入住我院。她长期服用利伐沙班预防血栓形成。分娩后,她停药半年,出现戒断症状。停药 4 个月后,她突然昏迷。诊断发现,这是蛛网膜下腔出血引起的。最终,她被诊断为矢状窦和横窦血栓形成。经过机械取栓治疗,她完全康复。总之,我们得出结论,机械取栓治疗 AT III 缺乏症和血栓形成是有效的。