气相色谱法测定血浆中氯氮䓬二钾（作者译）
[Determination of dipotassium clorazepate in the plasma by gas chromatography (author's transl)].
作者信息
Rey E, Turquais J M, Olive G
出版信息
Ann Biol Clin (Paris). 1978;36(4):355-8.
The authors present a method of estimation of dipotassium clorazepate by gas chromatography with a detector for electron capture. It requires 2 ml of blood. Two separate extractions are necessary, including one immediately after the sampling to determine the nordiazepam present at the time of the blood sample. The second extraction permits one to determine the total nordiazepam obtained by transformation of all the dipotassium clorazepate. This method is simple and rapid and permits one to determine with precision, specificity and good reproducibility (CV -- 3%) the therapeutic concentrations of this drug.
作者介绍了一种采用电子捕获检测器的气相色谱法来估算氯氮䓬二钾的方法。该方法需要2毫升血液。需要进行两次单独萃取，其中一次在采样后立即进行，以测定血样采集时存在的去甲西泮。第二次萃取可测定由所有氯氮䓬二钾转化得到的总去甲西泮。该方法简单快速，能够精确、特异且具有良好重现性（变异系数为3%）地测定该药物的治疗浓度。
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