编码血管紧张素转换酶2（ACE2）、跨膜丝氨酸蛋白酶2（TMPRSS2）及介导严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒进入的相关蛋白的基因，在人类心肌细胞中会随着年龄增长而上调。 - Suppr

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.

作者信息

Robinson Emma L, Alkass Kanar, Bergmann Olaf, Maguire Janet J, Roderick H Llewelyn, Davenport Anthony P

机构信息

Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University, The Netherlands and Laboratory of Experimental Cardiology, Dept. of Cardiovascular Sciences, KU Leuven, Campus Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium.

Karolinska Institutet, BioClinicum, Oncology and Pathology, The National Board of Forensic Medicine, SE-17177 Stockholm, Stockholm, Sweden.

出版信息

J Mol Cell Cardiol. 2020 Oct;147:88-91. doi: 10.1016/j.yjmcc.2020.08.009. Epub 2020 Aug 18.

DOI:10.1016/j.yjmcc.2020.08.009

PMID:32818486

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7431326/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/995e/7431326/96d47309b8ac/ga1_lrg.jpg

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Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.

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Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes.

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