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[高血压患者在不同功能负荷下血浆肾素总活性与活性及非活性肾素、血管紧张素原和血管紧张素II水平的相关性]

[Correlation of the total activity of blood plasma renin with levels of active and inactive renin, angiotensinogen and angiotensin II under different functional loads in patients with hypertension].

作者信息

Ustinova S E, Uchitel' I A, Masenko V P

出版信息

Kardiologiia. 1988 Jan;28(1):34-7.

PMID:3282115
Abstract

Components of the renin-angiotensin system (plasma renin activity, total and inactive renin, angiotensinogen and angiotensin II) were examined in 90 patients with labile and stable essential hypertension before and after functional and pharmacologic tests. New data have been obtained on intrasystemic regulatory mechanisms of the pressor renin-angiotensin systems. Different patterns of plasma active and inactive renin variations in response to salt loading are demonstrated in patients with different "renin" variants of essential hypertension. Angiotensin II is shown to have a stimulating effect on angiotensinogen synthesis.

摘要

在90例不稳定型和稳定型原发性高血压患者中,在功能和药理试验前后检测了肾素-血管紧张素系统的组成部分(血浆肾素活性、总肾素和无活性肾素、血管紧张素原和血管紧张素II)。已获得关于升压性肾素-血管紧张素系统的系统内调节机制的新数据。在原发性高血压不同“肾素”亚型的患者中,显示了对盐负荷反应时血浆活性和无活性肾素变化的不同模式。血管紧张素II对血管紧张素原合成具有刺激作用。

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