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[卡托普利对自发性高血压大鼠动脉血压、全身血流动力学及血浆肾素活性的影响]

[Effect of captopril on arterial pressure, systemic hemodynamics and renin activity in the blood plasma of rats with spontaneous hypertension].

作者信息

Pinelis V G, Vakulina T P, Poliak M G, Markov Kh M

出版信息

Kardiologiia. 1988 Jan;28(1):66-70.

PMID:3282117
Abstract

An angiotensin-I-converting enzyme, captopril, was administered since birth onward to normotensive (NR) and spontaneously hypertensive rats (SHR). It produced a marked hypotensive effect in SHR only. Cardiac output and circulating blood volume were similar in intact and experimental animals, NR and SHR alike. Captopril considerably increased plasma renin activity in NR and SHR.

摘要

从出生起就给正常血压大鼠（NR）和自发性高血压大鼠（SHR）施用一种血管紧张素转换酶抑制剂——卡托普利。结果发现，它仅对SHR产生显著的降压作用。完整动物和实验动物（包括NR和SHR）的心输出量和循环血容量相似。卡托普利可显著提高NR和SHR的血浆肾素活性。

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