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[红细胞的细胞骨架蛋白]

[The cytoskeletal proteins of erythrocytes].

作者信息

Goncharov E I, Pinaev G P

出版信息

Tsitologiia. 1988 Jan;30(1):5-18.

PMID:3282371
Abstract

The erythrocyte membrane skeleton is composed of the number of proteins isolated and characterized. One of the major proteins of cytoskeleton is actin presented in erythrocytes in the form of short protofilaments. This review will focus on the manner of attachment of actin protofilaments to the red cell membrane, and on the relationships between skeleton membrane proteins. Membrane skeleton proteins in erythrocytes are not unique. Recently a lot of proteins similar to the red cell membrane skeleton proteins were found in a wide variety of non-erythroid cells. This fact gives the opportunity to suppose the existence of a unique protein system in erythroid and non-erythroid cells which provides the attachment of actin filaments to cell membranes and which might be the centre for the assembling of actin structures in the cortical cytoplasm.

摘要

红细胞膜骨架由多种已分离和鉴定的蛋白质组成。细胞骨架的主要蛋白质之一是肌动蛋白,它在红细胞中以短原纤维的形式存在。本综述将聚焦于肌动蛋白原纤维与红细胞膜的附着方式,以及骨架膜蛋白之间的关系。红细胞中的膜骨架蛋白并非独一无二。最近,在多种非红细胞中发现了许多与红细胞膜骨架蛋白相似的蛋白质。这一事实使得我们有机会推测在红细胞和非红细胞中存在一种独特的蛋白质系统,该系统可使肌动蛋白丝附着于细胞膜,并且可能是皮质细胞质中肌动蛋白结构组装的中心。

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