Eidan Anthony, Ratsch Angela, Burmeister Elizabeth A, Griffiths Geraldine
Anesthetic Department, Bundaberg Hospital, Wide Bay Hospital and Health Service, Bundaberg 4670, Australia.
School of Medicine, The University of Queensland, Brisbane 4072, Australia.
Methods Protoc. 2020 Aug 13;3(3):58. doi: 10.3390/mps3030058.
The administration of opioids is a central element in contemporary anesthetic techniques in Australia; however, opioids have a range of side effects. As an alternative, opioid-free anesthesia (OFA) is an emerging mode of anesthesia intended to avoid these side effects. This study is the first to publish the use of OFA in Australia and is conducted in a regional Queensland Health Service. The design will utilize a randomized clinical trial (RCT) to investigate the impact of OFA for patients having an elective laparoscopic cholecystectomy ( = 40) or tubal ligation ( = 40). Participant outcomes to be measured include: Quality of Recovery (QoR-15); Oral Morphine Equivalent Daily Dose (OMEDD) at 24-h post-operatively; time to first opioid (TTFO) dose; post-operative nausea and vomiting (PONV); Post Anesthetic Care Unit length of stay (PACU-LOS); and hospital length of stay (LOS). The findings may challenge the essentiality of opioids in the peri-operative period, which in turn would influence the future intra-operative management of surgical patients. Ultimately, a reduction in anesthesia-associated opioid use will support a more general decline in opioid use.
在澳大利亚，阿片类药物的使用是当代麻醉技术的核心要素；然而，阿片类药物有一系列副作用。作为一种替代方法，无阿片类药物麻醉（OFA）是一种新兴的麻醉方式，旨在避免这些副作用。本研究首次发表了澳大利亚使用OFA的情况，且是在昆士兰地区卫生服务机构进行的。该设计将采用随机临床试验（RCT）来研究OFA对接受择期腹腔镜胆囊切除术（n = 40）或输卵管结扎术（n = 40）患者的影响。待测量的参与者结果包括：恢复质量（QoR-15）；术后24小时的口服吗啡等效日剂量（OMEDD）；首次使用阿片类药物的时间（TTFO）；术后恶心呕吐（PONV）；麻醉后护理病房住院时间（PACU-LOS）；以及住院时间（LOS）。这些发现可能会挑战阿片类药物在围手术期使用的必要性，进而影响未来手术患者的术中管理。最终，减少与麻醉相关的阿片类药物使用将有助于更广泛地减少阿片类药物的使用。
