Kaufman Harvey W, Gift Thomas L, Kreisel Kristen, Niles Justin K, Alagia Damian P
Quest Diagnostics, Information Ventures, Secaucus, New Jersey.
Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Am J Prev Med. 2020 Nov;59(5):697-703. doi: 10.1016/j.amepre.2020.05.023. Epub 2020 Aug 20.
This study aims to determine if and how the age distribution of Chlamydia trachomatis and Neisseria gonorrhoeae infections in women evolved from 2010 to 2017, given changes in sexual practices over this time.
All Chlamydia trachomatis/Neisseria gonorrhoeae co-testing laboratory results from females aged 12-30 years tested at Quest Diagnostics during 2010-2017 (n=17,794,680) were evaluated to assess trends in Chlamydia trachomatis and Neisseria gonorrhoeae positivity over time. Data were collected and analyzed in November 2018.
Age-based positivity shifted toward older ages from 2010 to 2017 for both Chlamydia trachomatis and Neisseria gonorrhoeae. There was a declining trend in Chlamydia trachomatis positivity from 2010 to 2017 for the youngest age group (12-17 years; 17% decline, 8.9% to 7.4%, p<0.0001) but increasing trends for both those aged 18-24 years (21% increase, 6.1% to 7.4%, p<0.0001) and 25-30 years (50% increase, 2.2% to 3.3%, p<0.0001). The Chlamydia trachomatis positivity rate for 27-year-olds in 2017 (3.5%) and 24-year-olds in 2010 (3.5%) was the same. Similarly, there was a declining trend in Neisseria gonorrhoeae positivity from 2010 to 2017 for the youngest age group (12-17 years; 14% decline, 1.33% vs 1.17%, p<0.0001) but increasing trends for both those aged 18-24 years (27% increase, 0.79% vs 1.00%, p<0.0001) and 25-30 years (117% increase, 0.29% vs 0.63%, p<0.0001). For Neisseria gonorrhoeae, 30-year-old women tested in 2017 had an identical positivity rate to 23-year-old women tested in 2010, at 0.5%.
Healthcare providers may want to consider this positivity rate age shift in Chlamydia trachomatis and Neisseria gonorrhoeae to inform prevention and control strategies, including considering the potential for increased risk in women aged 25-30 years.
鉴于这段时间内性行为的变化，本研究旨在确定2010年至2017年期间女性沙眼衣原体和淋病奈瑟菌感染的年龄分布是否以及如何演变。
对2010年至2017年期间在奎斯特诊断公司接受检测的12至30岁女性的所有沙眼衣原体/淋病奈瑟菌联合检测实验室结果（n = 17,794,680）进行评估，以评估沙眼衣原体和淋病奈瑟菌阳性率随时间的变化趋势。数据于2018年11月收集和分析。
2010年至2017年，沙眼衣原体和淋病奈瑟菌基于年龄的阳性率均向年龄较大的方向转变。最年轻年龄组（12至17岁）的沙眼衣原体阳性率从2010年至2017年呈下降趋势（下降17%，从8.9%降至7.4%，p<0.0001），但18至24岁年龄组（增加21%，从6.1%增至7.4%，p<0.0001）和25至30岁年龄组（增加50%，从2.2%增至3.3%，p<0.0001）均呈上升趋势。2017年27岁女性的沙眼衣原体阳性率（3.5%）与2010年24岁女性的相同（3.5%）。同样，最年轻年龄组（12至17岁）的淋病奈瑟菌阳性率从2010年至2017年呈下降趋势（下降14%，从1.33%降至1.17%，p<0.0001），但18至24岁年龄组（增加27%，从0.79%增至1.00%，p<0.0001）和25至30岁年龄组（增加117%，从0.29%增至0.63%，p<0.0001）均呈上升趋势。对于淋病奈瑟菌，2017年检测的30岁女性的阳性率与2010年检测的23岁女性相同，为0.5%。
医疗保健提供者可能需要考虑沙眼衣原体和淋病奈瑟菌阳性率的这种年龄转变，以指导预防和控制策略，包括考虑25至30岁女性风险增加的可能性。
