Department of Obstetrics, Gynecology and Human Reproduction, CHU Anne De Bretagne, Rennes, France.
Department of Pathological Anatomy and Cytology, CHU Pontchaillou, Rennes, France.
J Gynecol Obstet Hum Reprod. 2021 Jan;50(1):101896. doi: 10.1016/j.jogoh.2020.101896. Epub 2020 Aug 20.
Paget's disease of the vulva is a rare form of extramammary Paget's disease mainly affecting postmenopausal women. Its pathophysiology remains largely unknown. Up to fairly recently, the only treatment for this disease was surgery, often mutilating the vulva, with significant psychosexual repercussions without the assurance of complete therapeutic efficacy. New therapeutic approaches -topical treatments, radiotherapy or chemotherapy- have emerged in recent years but lack consensual guidelines. We present a literature review of the recent results published in this field.
外阴佩吉特病是一种罕见的乳腺外佩吉特病，主要影响绝经后妇女。其病理生理学仍知之甚少。直到最近，这种疾病的唯一治疗方法是手术，通常会对外阴造成严重的损伤，带来显著的心理性影响，而且不能保证完全的治疗效果。近年来出现了一些新的治疗方法，如局部治疗、放疗或化疗，但缺乏共识性的指南。我们对该领域最近发表的文献进行了回顾。
