Abelleira Romina, Zamarrón Carlos, Ruano Alberto, Lourido Tamara, Rodríguez-Núñez Nuria, González-Barcala Francisco J, Toubes María E, Álvarez-Dobaño José M, Ricoy Jorge, Valdés Luis
Servicio de Neumología, Hospital Universitario de Santiago de Compostela, Santiago de Compostela, España.
Servicio de Neumología, Hospital Universitario de Santiago de Compostela, Santiago de Compostela, España.
Med Clin (Barc). 2021 Aug 13;157(3):106-113. doi: 10.1016/j.medcli.2020.05.060. Epub 2020 Aug 21.
Diabetes mellitus and sleep apnoea-hypopnoea syndrome appear to be related, but it is not well defined whether there is an increased risk of peripheral neuropathy in patients with both diseases. For this reason, we conducted a systematic review.
Bibliographic search in 3 electronic databases using a predefined strategy and the PRISMA methodology. Only original studies (any type of design) published from 2000 onwards in English, French, Portuguese or Spanish were included. A study quality scale was established.
Twelve articles were selected, of which six studied type 2 diabetic patients. The overall prevalence of sleep apnoea-hypopnoea syndrome was 43.7% (1,559/3,564 patients). Diabetic neuropathy was more frequent in patients with sleep apnoea-hypopnoea syndrome in nine studies, although significantly only in four (60% vs 27%, P<.001; 64.5% vs 36%, P=.03; 37% vs 23.4%, P<.02; 66.6% vs 0%, P=.007). In one study, diabetic neuropathy was more frequent in patients without sleep apnoea-hypopnoea syndrome (although not statistically significant) and in 2 no comparison was made between patients with/without sleep apnoea/hypopnoea syndrome.
The observed results suggest a relationship between diabetes mellitus and sleep apnoea-hypopnoea syndrome in the occurrence of diabetic neuropathy.
糖尿病与睡眠呼吸暂停低通气综合征似乎有关联，但两种疾病并存的患者发生周围神经病变的风险是否增加尚不清楚。因此，我们进行了一项系统评价。
采用预定义策略和PRISMA方法在3个电子数据库中进行文献检索。仅纳入2000年以后以英文、法文、葡萄牙文或西班牙文发表的原创研究（任何类型的设计）。建立了研究质量量表。
筛选出12篇文章，其中6篇研究2型糖尿病患者。睡眠呼吸暂停低通气综合征的总体患病率为43.7%（1559/3564例患者）。在9项研究中，睡眠呼吸暂停低通气综合征患者的糖尿病神经病变更为常见，尽管只有4项研究具有统计学意义（60%对27%，P<0.001；64.5%对36%，P=0.03；37%对23.4%，P<0.02；66.6%对0%，P=0.007）。在1项研究中，无睡眠呼吸暂停低通气综合征的患者糖尿病神经病变更为常见（尽管无统计学意义），2项研究未对有无睡眠呼吸暂停低通气综合征的患者进行比较。
观察结果提示糖尿病与睡眠呼吸暂停低通气综合征在糖尿病神经病变的发生中存在关联。
