Wang Mu, Chu Fuke, Xiao Jingjing, Choi Bonnie, Wei Xiaohu, Feng Anchao
Sinopec Research Institute of Petroleum Engineering, Beijing, 100101, China.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Macromol Rapid Commun. 2020 Oct;41(19):e2000352. doi: 10.1002/marc.202000352. Epub 2020 Aug 23.
Macromolecules have a strong tendency to interact with each other in solution to form a supramolecular structure through various secondary binding forces. In this study, nucleobase-containing templates poly(9-(4-vinylbenzyl)adenine) (P AH) and poly(1-(4-vinylbenzyl)cytosine) (P CH) are prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. Vinylbenzyl thymine (M T) is polymerized in the presence of these two nucleobase-containing templates. M T shows higher affinities toward the template P AH compared with the template P CH. In accordance with the Watson-Crick pairing principle, thymine forms hydrogen bonding (H-bonding) with adenine, but not between thymine and cytosine. A complex is formed when P AH is used as template which indicates that there is a template polymerization of nucleobase complexes via molecular recognition.
在溶液中，大分子有强烈的相互作用倾向，通过各种二级结合力形成超分子结构。在本研究中，通过可逆加成-断裂链转移（RAFT）聚合制备了含核碱基的模板聚（9-（4-乙烯基苄基）腺嘌呤）（PAH）和聚（1-（4-乙烯基苄基）胞嘧啶）（PCH）。乙烯基苄基胸腺嘧啶（MT）在这两种含核碱基的模板存在下进行聚合。与模板PCH相比，MT对模板PAH表现出更高的亲和力。根据沃森-克里克配对原则，胸腺嘧啶与腺嘌呤形成氢键，但胸腺嘧啶与胞嘧啶之间不形成氢键。当使用PAH作为模板时会形成复合物，这表明通过分子识别存在核碱基复合物的模板聚合。
