咪唑修饰的 Pt(iv)前药负载的多阶段 pH 响应纳米粒以克服顺铂耐药性。
Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance.
机构信息
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, P. R. China.
出版信息
Chem Commun (Camb). 2020 Sep 28;56(76):11271-11274. doi: 10.1039/d0cc01846e. Epub 2020 Aug 24.
PMID:32830841
Abstract
An imidazole modified Pt(iv) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.
摘要
一种具有长脂质尾巴的咪唑修饰的 Pt(iv)前药，可以通过与带负电荷的亲水性聚合物静电络合，自组装成多阶段 pH 响应纳米粒子。该策略可以显著克服顺铂耐药性。
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