Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China.
Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai 200031, China.
Dis Markers. 2020 Aug 1;2020:7241785. doi: 10.1155/2020/7241785. eCollection 2020.
This retrospective study aims at comparing the variation of peripheral inflammatory markers in recurrent and cancerous vocal fold leukoplakia (VFL) and at exploring the potential connection with pathological outcomes.
The patients undergoing carbon dioxide laser surgery with postoperative pathological diagnosis of recurrent vocal fold leukoplakia in the last 5 years were included. The clinical data were collected, and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocytes-to-lymphocyte ratio (MLR) before and after recurrence and canceration were calculated. Related comparison with two-grade pathological classification was made to evaluate their potential connection with postsurgical histopathology and clinical events.
The data of 193 patients were engaged into research, as 111 in the recurrence group (Group A) and 82 in canceration group (Group B). The NLR, PLR, and MLR were significantly increased in canceration event compared to the first ( = 0.009, 0.004, 0.007, respectively) and penultimate ( = 0.013, 0.041, 0.006, respectively) time when the previous pathologies were leukoplakia. When redividing the Group A according to the two-grade pathological classification, the high-risk groups showed statistically higher NLR and PLR values than low-risk groups in the subgroups with grade changing ( = 0.016, 0.005, 0.007, 0.005, respectively) and subgroups without grade changing ( = 0.020, 0.027, 0.030, 0.029, respectively).
NLR, PLR, and MLR are reliable biomarkers in the circulation system which show significantly interrelation with the pathological progression of vocal fold leukoplakia. Presurgical evaluation of NLR, PLR, and MLR may have potential values to indicate the following treatment in clinical practice.
本回顾性研究旨在比较复发性和癌性声带白斑（VFL）外周炎症标志物的变化，并探讨其与病理结果的潜在联系。
纳入过去 5 年内接受二氧化碳激光手术且术后病理诊断为复发性声带白斑的患者。收集临床资料，计算复发和癌变前后中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和单核细胞与淋巴细胞比值（MLR），并与两级病理分级进行相关比较，以评估其与术后组织病理学和临床事件的潜在联系。
共纳入 193 例患者的数据，其中 111 例在复发组（A 组），82 例在癌变组（B 组）。与首次（=0.009、0.004、0.007，分别）和前一次（=0.013、0.041、0.006，分别）病变为白斑时相比，癌变事件中 NLR、PLR 和 MLR 显著升高。当根据两级病理分级重新划分 A 组时，在分级变化（=0.016、0.005、0.007、0.005，分别）和分级不变（=0.020、0.027、0.030、0.029，分别）亚组中，高危组的 NLR 和 PLR 值均显著高于低危组。
NLR、PLR 和 MLR 是循环系统中可靠的生物标志物，与声带白斑的病理进展有显著的相关性。术前评估 NLR、PLR 和 MLR 可能具有潜在价值，可在临床实践中指导后续治疗。
