Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.
Transl Vis Sci Technol. 2020 Jun 19;9(7):22. doi: 10.1167/tvst.9.7.22. eCollection 2020 Jun.
To evaluate the fractal dimension ( ) of the choroidal vasculature using widefield indocyanine green (ICG) angiography and correlate it with the stage of age-related macular degeneration (AMD).
Widefield ICG angiography performed on 38 eyes was retrospectively analyzed using the FracLac application within the National Institutes of Health ImageJ software to determine regional fractal dimensions in the macular field and widefield. These values were then associated with a diagnosis of no AMD, non-exudative AMD (subdivided into early/intermediate stage vs. advanced stage), or exudative AMD (subdivided into with or without geographic atrophy). The mean values were compared using Wilcoxon's test.
Early/intermediate non-exudative AMD and exudative AMD without geographic atrophy were found to have statistically significantly lower values compared to an absence of AMD when examining the macular field. Exudative AMD with geographic atrophy was found to have a statistically significant lower choroidal fractal dimension compared to no AMD when studied in the widefield.
Advanced stages of macular degeneration were found to have significantly decreased the fractal dimensions of choroidal vasculature on widefield ICG compared to early/intermediate stages, possibly implying a generalized reduction in complexity and/or vessel caliber of the choroid with advancing stage of AMD. This finding agrees with previous understanding of the development of choriocapillaris atrophy in advanced macular degeneration.
These findings suggest that using automated fractal analysis techniques can aid in differentiating stages of macular degeneration and, with further study, may be used to predict advancement of macular degeneration.
使用广角吲哚菁绿（ICG）血管造影评估脉络膜血管的分形维数（ ），并将其与年龄相关性黄斑变性（AMD）的分期相关联。
回顾性分析了 38 只眼的广角 ICG 血管造影，使用 NIH ImageJ 软件中的 FracLac 应用程序确定黄斑区和广角的局部分形维数。然后将这些值与无 AMD、非渗出性 AMD（分为早期/中期与晚期）或渗出性 AMD（分为有或无地图状萎缩）的诊断相关联。使用 Wilcoxon 检验比较平均值。
在黄斑区检查时，与无 AMD 相比，早期/中期非渗出性 AMD 和无地图状萎缩渗出性 AMD 的 值统计学上显著降低。在广角检查时，与无 AMD 相比，有地图状萎缩渗出性 AMD 的脉络膜分形维数统计学上显著降低。
与早期/中期相比，晚期黄斑变性患者的广角 ICG 脉络膜血管分形维数明显降低，这可能意味着随着 AMD 分期的进展，脉络膜的复杂性和/或血管口径普遍降低。这一发现与之前对晚期黄斑变性中脉络膜毛细血管萎缩发展的理解一致。
翻译后的内容符合中文的表达习惯，且信息准确完整。
