Yang Li, Lewis Kyle
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Division of Gastroenterology, Hepatology & Nutrition Developmental Biology Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
J Clin Transl Hepatol. 2020 Jun 28;8(2):177-183. doi: 10.14218/JCTH.2019.00031. Epub 2020 Jun 8.
The lineage of the erythroid cell has been revisited in recent years. Instead of being classified as simply inert oxygen carriers, emerging evidence has shown that they are a tightly regulated in immune potent population with potential developmental plasticity for lineage crossing. Erythroid cells have been reported to exert immune regulatory function through secreted cytokines, or cell-cell contact, depending on the conditions of the microenvironment and disease models. In this review, we explain the natural history of erythroid cells in the liver through a developmental lens, as it offers perspectives into newly recognized roles of this lineage in liver biology. Here, we review the known immune roles of erythroid cells and discuss the mechanisms in the context of disease models and stages. Then, we explore the capability of erythroid lineage as a cell source for regenerative medicine. We propose that the versatile lineage of erythroid cells provides an underappreciated and potentially promising area for basic and translational research in the field of liver disease.
近年来，红细胞系已被重新审视。新兴证据表明，红细胞并非仅仅被归类为惰性氧载体，而是一个受到严格调控的具有免疫潜能的群体，具有跨谱系发育可塑性。据报道，红细胞可根据微环境和疾病模型的条件，通过分泌细胞因子或细胞间接触发挥免疫调节功能。在这篇综述中，我们从发育的角度解释肝脏中红细胞的自然史，因为它为该谱系在肝脏生物学中的新认识作用提供了视角。在这里，我们回顾红细胞已知的免疫作用，并在疾病模型和阶段的背景下讨论其机制。然后，我们探索红细胞系作为再生医学细胞来源的能力。我们认为，红细胞的多功能谱系为肝病领域的基础研究和转化研究提供了一个未得到充分重视但颇具潜力的领域。
