Schmidt-Gollwitzer M, Hardt W, Schmidt-Gollwitzer K, Michel E, Nevinny-Stickel J
Geburtshilfe Frauenheilkd. 1977 Jun;37(6):500-8.
The effect of Ablacton, Estrovis 4000, 2 Brom-alpha-ergokryptin (Cb 154) and of Lisurid-hydrogenmaleate (LHM) on lactation and the serum concentration of prolactin postpartum was studied. 10 normal nursing postpartum patients served as control. LHM was tested in a double blind study compared to placebo. The serum prolactin (PRL) was determined daily for the first 10 postpartum days by radioimmunoassay. Inhibition of lactation was consistent with Cb 154 (89% of the cases). Within two to three days after the onset of treatment with Cb 154 the changes of pregnancy in the breasts had completely subsided. The sexual steroids resulted in inhibition of lactation in 60% of the postpartum patients but mastodynia continued. LHM showed no difference from group taking placebo. The serum prolactin levels postpartum remained as high as a nursing mother's or rose with the administration of steroids. The administration of Cb 154 resulted in a drop of the serum prolactin to non-pregnant levels with in 2 days. The serum prolactin levels under treatment with LHM were not different from the group slowly. In nursing mothers, the stimulus of suckling maintain the pituitary secretion of prolactin as showed by higher serum prolactin levels and a slower decreased to normals than in the non-nursing mothers.
研究了回奶宝、复方戊酸雌二醇片（补佳乐）、2-溴-α-麦角隐亭（CB 154）和马来酸氢麦角乙脲（LHM）对产后泌乳及血清催乳素浓度的影响。10名正常产后哺乳患者作为对照。LHM与安慰剂进行双盲研究。产后头10天每天用放射免疫分析法测定血清催乳素（PRL）。CB 154对泌乳的抑制作用明显（89%的病例）。在用CB 154治疗开始后的两到三天内，乳房的妊娠变化完全消退。性类固醇导致60%的产后患者泌乳受到抑制，但乳房疼痛持续存在。LHM与服用安慰剂组无差异。产后血清催乳素水平与哺乳母亲一样高，或随着类固醇的给药而升高。服用CB 154导致血清催乳素在2天内降至非妊娠水平。LHM治疗组的血清催乳素水平与对照组无差异。在哺乳母亲中，哺乳刺激维持了垂体催乳素的分泌，表现为血清催乳素水平较高，且降至正常水平的速度比非哺乳母亲慢。
