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Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19.

作者信息

Stahl Klaus, Gronski Phillip Alexander, Kiyan Yulia, Seeliger Benjamin, Bertram Anna, Pape Thorben, Welte Tobias, Hoeper Marius M, Haller Hermann, David Sascha

机构信息

Hannover Medical School Hannover, Germany and.

University Hospital Zurich Zurich, Switzerland.

出版信息

Am J Respir Crit Care Med. 2020 Oct 15;202(8):1178-1181. doi: 10.1164/rccm.202007-2676LE.

DOI:10.1164/rccm.202007-2676LE
PMID:32833500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7560808/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/7560808/952601e76d02/rccm.202007-2676LEf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/7560808/952601e76d02/rccm.202007-2676LEf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5770/7560808/952601e76d02/rccm.202007-2676LEf1.jpg

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引用本文的文献

[1]
Endothelial Activation and Permeability in Patients on VV-ECMO Support: An Exploratory Study.

J Clin Med. 2025-7-9

[2]
Current understanding of heparanase 2 regulation, a non-heparanase.

Biochem Soc Trans. 2025-2-5

[3]
Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms.

NPJ Syst Biol Appl. 2025-1-13

[4]
Tumor- and host-derived heparanase-2 (Hpa2) attenuates tumorigenicity: role of Hpa2 in macrophage polarization and BRD7 nuclear localization.

Cell Death Dis. 2024-12-18

[5]
CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID.

Nat Cardiovasc Res. 2024-10

[6]
Association between Age-Adjusted Endothelial Activation and Stress Index and Intensive Care Unit Mortality in Patients with Severe COVID-19.

Tuberc Respir Dis (Seoul). 2024-10

[7]
Protecting the endothelial glycocalyx in COVID-19.

PLoS Pathog. 2024-5-16

[8]
Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling.

Biofabrication. 2024-6-5

[9]
Herpesvirus Infection of Endothelial Cells as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Viruses. 2024-4-8

[10]
Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications.

Cell Commun Signal. 2024-4-25

本文引用的文献

[1]
Endothelial cell infection and endotheliitis in COVID-19.

Lancet. 2020-5-2

[2]
Covid-19 in Critically Ill Patients in the Seattle Region - Case Series.

N Engl J Med. 2020-3-30

[3]
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.

JAMA Cardiol. 2020-7-1

[4]
Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling.

Sci Rep. 2019-9-19

[5]
The glycocalyx: a novel diagnostic and therapeutic target in sepsis.

Crit Care. 2019-1-17

[6]
Endothelial glycocalyx breakdown is mediated by angiopoietin-2.

Cardiovasc Res. 2017-5-1

[7]
The Endothelial Glycocalyx: New Diagnostic and Therapeutic Approaches in Sepsis.

Biomed Res Int. 2016

[8]
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.

Nat Med. 2012-7-22

[9]
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.

J Biol Chem. 2010-6-24

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