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短链脂肪酸受体的代谢和炎症功能。

Metabolic and inflammatory functions of short-chain fatty acid receptors.

作者信息

Bolognini Daniele, Dedeo Domonkos, Milligan Graeme

机构信息

Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.

出版信息

Curr Opin Endocr Metab Res. 2021 Feb;16:1-9. doi: 10.1016/j.coemr.2020.06.005. Epub 2020 Jul 3.

DOI:10.1016/j.coemr.2020.06.005
PMID:32835130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7332907/
Abstract

FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders.

摘要

游离脂肪酸受体2（FFA2）和游离脂肪酸受体3（FFA3）是短链脂肪酸的受体，肠道细菌对消化不完全的碳水化合物进行发酵会大量产生短链脂肪酸。随着新型药理学工具和动物模型的产生与应用，人们对这些受体在调节肠内分泌、代谢和免疫功能方面的作用有了进一步了解。目前正在出现一种复杂的（病理）生理情况，即FFA2和FFA3在关键细胞类型中的策略性表达及其信号传导的选择性调节可能会对体重管理、能量稳态和炎症性疾病产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e49/7962094/75823dbfdf71/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e49/7962094/8773532c7459/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e49/7962094/75823dbfdf71/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e49/7962094/8773532c7459/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e49/7962094/75823dbfdf71/gr2.jpg

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Metabolic and inflammatory functions of short-chain fatty acid receptors.

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[6]
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[7]
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本文引用的文献

[1]
Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release.

iScience. 2020-8-12

[2]
Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice.

Sci Rep. 2020-5-13

[3]
Bifidobacterium animalis subsp. lactis GCL2505 modulates host energy metabolism via the short-chain fatty acid receptor GPR43.

Sci Rep. 2020-3-5

[4]
Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production.

Cell Rep. 2020-3-3

[5]
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.

Science. 2020-2-28

[6]
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils.

Biochim Biophys Acta Mol Cell Res. 2020-2-21

[7]
Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.

Am J Physiol Regul Integr Comp Physiol. 2020-2-19

[8]
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.

J Exp Med. 2020-3-2

[9]
Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon.

Int Immunol. 2020-4-12

[10]
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.

J Virol. 2020-1-6

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