• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

采用熔融挤出法制备脂质基药物递送系统。

The preparation of lipid-based drug delivery system using melt extrusion.

作者信息

Chauhan Gautam, Shaik Abdul A, Kulkarni Nishant S, Gupta Vivek

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA; Current address: School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

出版信息

Drug Discov Today. 2020 Aug 21. doi: 10.1016/j.drudis.2020.07.025.

DOI:10.1016/j.drudis.2020.07.025
PMID:32835807
Abstract

Melt extrusion of lipids is versatile with high applicability in the pharmaceutical industry. The formulations prepared can be easily customized depending on the requirements, and have the potential to open a window on personalized medicine.

摘要

脂质的熔融挤出具有通用性，在制药行业具有很高的适用性。所制备的制剂可根据需求轻松定制，并有潜力为个性化医疗打开一扇窗。

相似文献

1
The preparation of lipid-based drug delivery system using melt extrusion.采用熔融挤出法制备脂质基药物递送系统。
Drug Discov Today. 2020 Aug 21. doi: 10.1016/j.drudis.2020.07.025.
2
Recent studies on the processes and formulation impacts in the development of solid dispersions by hot-melt extrusion.近期关于热熔挤出法制备固体分散体过程和配方影响的研究。
Eur J Pharm Biopharm. 2021 Jul;164:13-19. doi: 10.1016/j.ejpb.2021.04.009. Epub 2021 Apr 19.
3
An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part II.二十一世纪热熔挤出技术在新型药物传递中的应用进展更新：第二部分。
Expert Opin Drug Deliv. 2019 Jun;16(6):567-582. doi: 10.1080/17425247.2019.1614912. Epub 2019 May 14.
4
Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion.热熔挤出法制备固体自微乳药物传递系统。
Int J Pharm. 2018 Apr 25;541(1-2):1-10. doi: 10.1016/j.ijpharm.2018.02.020. Epub 2018 Feb 16.
5
Recent Perspectives in Hot Melt Extrusion-Based Polymeric Formulations for Drug Delivery: Applications and Innovations.近年来热熔挤出技术在药物传递中的应用及创新：聚合物配方的新视角。
AAPS PharmSciTech. 2019 Jan 28;20(3):92. doi: 10.1208/s12249-019-1300-8.
6
Lipid-based solubilization technology via hot melt extrusion: promises and challenges.基于脂质的热熔挤出增溶技术：前景与挑战。
Expert Opin Drug Deliv. 2022 Sep;19(9):1013-1032. doi: 10.1080/17425247.2022.2112173. Epub 2022 Aug 18.
7
Hot-melt extrusion--basic principles and pharmaceutical applications.热熔挤出——基本原理及药物应用
Drug Dev Ind Pharm. 2014 Sep;40(9):1133-55. doi: 10.3109/03639045.2013.838577. Epub 2014 Feb 13.
8
A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing.热熔挤出及其与 3D 打印相结合的延释口服制剂的全面概述。
Int J Pharm. 2021 Mar 1;596:120237. doi: 10.1016/j.ijpharm.2021.120237. Epub 2021 Jan 21.
9
Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion.载有通过热熔挤出制备的无定形固体分散体的双机制胃滞留药物递送系统。
Eur J Pharm Sci. 2017 May 1;102:71-84. doi: 10.1016/j.ejps.2017.02.040. Epub 2017 Feb 28.
10
Melt extrusion: from process to drug delivery technology.熔融挤出：从工艺到药物递送技术
Eur J Pharm Biopharm. 2002 Sep;54(2):107-17. doi: 10.1016/s0939-6411(02)00061-9.

引用本文的文献

1
A Review on QbD-Driven Optimization of Lipid Nanoparticles for Oral Drug Delivery: From Framework to Formulation.基于质量源于设计的口服给药脂质纳米粒优化研究综述：从框架到制剂
Int J Nanomedicine. 2025 Jul 3;20:8611-8651. doi: 10.2147/IJN.S534137. eCollection 2025.
2
Scalable Production and In Vitro Efficacy of Inhaled Erlotinib Nanoemulsion for Enhanced Efficacy in Non-Small Cell Lung Cancer (NSCLC).可扩展生产及吸入式厄洛替尼纳米乳剂在非小细胞肺癌（NSCLC）中的体外疗效：增强疗效
Pharmaceutics. 2023 Mar 20;15(3):996. doi: 10.3390/pharmaceutics15030996.
3
Anticancer Applications of Essential Oils Formulated into Lipid-Based Delivery Nanosystems.
调配至基于脂质的递送纳米系统中的精油的抗癌应用。
Pharmaceutics. 2022 Dec 1;14(12):2681. doi: 10.3390/pharmaceutics14122681.
4
Design Optimization and Evaluation of Solid Lipid Nanoparticles of Azelnidipine for the Treatment of Hypertension.用于治疗高血压的阿折地平固体脂质纳米粒的设计优化与评价
Recent Pat Nanotechnol. 2024;18(1):22-32. doi: 10.2174/1872210517666221019102543.
5
Functional Excipients and Novel Drug Delivery Scenario in Self-nanoemulsifying Drug Delivery System: A Critical Note.自纳米乳化药物递送系统中的功能性辅料与新型药物递送方案：一篇评论
Pharm Nanotechnol. 2022 Aug 29. doi: 10.2174/2211738510666220829085745.
6
Development and Characterization of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology.采用热熔挤出技术制备盐酸多奈哌齐缓释固体分散体及其表征
Pharmaceutics. 2021 Feb 4;13(2):213. doi: 10.3390/pharmaceutics13020213.
7
Nanoindentation of Graphene/Phospholipid Nanocomposite: A Molecular Dynamics Study.石墨烯/磷脂纳米复合材料的纳米压痕：分子动力学研究。
Molecules. 2021 Jan 11;26(2):346. doi: 10.3390/molecules26020346.