Pillunat L E, Stodtmeister R
Universitäts-Augenklinik, Ulm, BRD.
Ophthalmologica. 1988;196(2):67-75. doi: 10.1159/000309878.
The aim of the present study was to show the effect of different topical beta-blocking agents on aqueous humor formation with a clinically practicable method. In a clinical, randomized, prospective double-blind study, 60 healthy volunteers were examined by means of oculopression tonometry according to Ulrich. The placebo was applied to 29 subjects; a nonselective beta-blocker (timolol maleate 0.5%) was given to 14 volunteers and 17 subjects received a cardioselective, beta-1-blocking agent (betaxolol-HCl 0.5%). On the 1st day, intraocular pressure (IOP) was lowered by the suction cup method and then we measured the time required for IOP to return to the initial value. The examination procedure of the 1st day was repeated on the 2nd day 3 h after application of the ophthalmic solution. After evaluation of the different groups, we could show that the recovery times in the placebo groups were comparable. Furthermore, we showed that both beta-blockers slow down the increase of IOP to the initial value. There was a statistically significant difference in recovery time between timolol and placebo. This difference was statistically not significant between betaxolol and placebo.
本研究的目的是用一种临床可行的方法来展示不同局部β受体阻滞剂对房水生成的影响。在一项临床随机前瞻性双盲研究中，60名健康志愿者按照乌尔里希眼压测量法接受了眼压迫眼压测量检查。29名受试者使用了安慰剂；14名志愿者使用了非选择性β受体阻滞剂（0.5%马来酸噻吗洛尔），17名受试者使用了心脏选择性β1受体阻滞剂（0.5%盐酸倍他洛尔）。在第一天，通过吸盘法降低眼内压（IOP），然后我们测量IOP恢复到初始值所需的时间。在第二天，在应用眼药水3小时后重复第一天的检查程序。在对不同组进行评估后，我们发现安慰剂组的恢复时间相当。此外，我们还发现两种β受体阻滞剂都减缓了IOP回升到初始值的速度。噻吗洛尔和安慰剂之间的恢复时间存在统计学上的显著差异。倍他洛尔和安慰剂之间的这种差异在统计学上不显著。
