Grant B F, Dufour M C, Harford T C
Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20857.
Semin Liver Dis. 1988 Feb;8(1):12-25. doi: 10.1055/s-2008-1040525.
Although there exists a relationship between alcohol consumption and alcoholic liver disease at both the aggregate and individual levels, it is also well established that less than one-third of alcoholics or heavy drinkers develop serious alcohol-related liver damage. A number of factors have been proposed to account for this susceptibility. Evidence supporting the direct dose-response relationship and the role of genetic and environmental factors in influencing vulnerability are reviewed. To date, no consistent evidence attests to the significance of any one factor in the susceptibility to developing alcoholic liver disease.
尽管在总体和个体层面上，饮酒与酒精性肝病之间都存在关联，但同样确定的是，不到三分之一的酗酒者或大量饮酒者会出现严重的酒精相关肝损伤。人们提出了许多因素来解释这种易感性。本文综述了支持直接剂量反应关系以及遗传和环境因素在影响易感性方面作用的证据。迄今为止，尚无一致的证据证明任何一个因素在酒精性肝病易感性中的重要性。
