健康成年人心脏 MRI 的 T2 弛豫时间：系统评价和荟萃分析。
T2 Relaxation Times at Cardiac MRI in Healthy Adults: A Systematic Review and Meta-Analysis.
机构信息
From the Department of Medicine, Cardiovascular Division (C.A.H., M.S.), Department of Medicine (A.K., S.I.), and Department of Radiology (M.S.), University of Virginia Health System, 1215 Lee St, Box 800158, Charlottesville, VA 22908; Department of Medicine, Cardiovascular Division, University of Massachusetts, Worcester, Mass (M.G.); and Department of Biomedical Engineering, University of Virginia, Charlottesville, Va (M.S.).
出版信息
Radiology. 2020 Nov;297(2):344-351. doi: 10.1148/radiol.2020200989. Epub 2020 Aug 25.
Background T2 mapping is an important cardiac MRI technique with applications in various conditions. However, a comprehensive evaluation of the T2 literature for normal values is lacking. Purpose To characterize the ranges of normal values and variability of myocardial T2 relaxation times using a systematic review and meta-analysis of the T2 literature. Materials and Methods PubMed and Cochrane Central were searched from June 2019 to January 2020 for myocardial T2 measurements in healthy adults. Studies quantifying T2 relaxation times conducted at 1.5 T or 3.0 T using gradient and spin-echo (GRASE) or T2-prepared balanced steady-state free precession sequences were included. Summary means were generated using a random-effects model. Subgroup analysis and meta-regression were performed to assess factors causing heterogeneity. Results Of the 2481 articles retrieved, 42 studies were included with 954 healthy adults (mean age, 42.4 years ± 10.5 [standard deviation]; 538 men). The pooled mean of T2 across studies was 52 msec at 1.5 T (95% confidence interval [CI]: 51 msec, 53 msec) and 46 msec at 3.0 T (95% CI: 44 msec, 48 msec) ( ≤ .001). was 98% at 1.5 T and 3.0 T. Meta-regression at 1.5 T and 3.0 T identified vendor (β at 1.5 T = -4 msec [with Philips as reference], < .001; β at 3.0 T = -5 msec, = .02) and pulse sequence (β at 1.5 T = -5 msec [with GRASE as reference], < .001; β at 3.0 T = -6 msec, = .002) as significant covariates, but it did not identify any association with covariates of age (β at 1.5 T = 0 msec per year, = .70; β at 3.0 T = 0 msec per year, = .83) or sex (β at 1.5 T = -1 msec, = .88; β at 3.0 T = 6 msec, = .42). Conclusion The pooled mean of T2 relaxation times in healthy adults had marked heterogeneity across studies with field strength, vendor, and pulse sequence identified as covariates associated with T2. T2-prepared measurements were similar between vendors at each field strength. © RSNA, 2020
背景 T2 映射是一种重要的心脏 MRI 技术，适用于各种情况。然而，目前缺乏对 T2 文献中正常数值的全面评估。目的 使用 T2 文献的系统评价和荟萃分析，描述心肌 T2 弛豫时间正常范围和变异性。材料与方法 2019 年 6 月至 2020 年 1 月，在 PubMed 和 Cochrane Central 数据库中检索了关于健康成年人心肌 T2 测量的文献。纳入了使用梯度回波（GRASE）或 T2 准备平衡稳态自由进动序列定量测量 T2 弛豫时间的研究。使用随机效应模型生成汇总均值。进行了亚组分析和荟萃回归，以评估导致异质性的因素。结果 在检索到的 2481 篇文章中，有 42 篇研究纳入了 954 名健康成年人（平均年龄 42.4 岁±10.5[标准差]；538 名男性）。研究中 T2 的汇总平均值在 1.5 T 为 52 msec（95%置信区间：51 msec，53 msec），在 3.0 T 为 46 msec（95%置信区间：44 msec，48 msec）（<.001）。在 1.5 T 和 3.0 T 时， 的值均为 98%。在 1.5 T 和 3.0 T 时的荟萃回归分析确定了供应商（在 1.5 T 时，β值为-4 msec[以飞利浦为参照]，<.001；在 3.0 T 时，β值为-5 msec，=.02）和脉冲序列（在 1.5 T 时，β值为-5 msec[以 GRASE 为参照]，<.001；在 3.0 T 时，β值为-6 msec，=.002）为显著的协变量，但未发现年龄（在 1.5 T 时，β值为每年 0 msec，=.70；在 3.0 T 时，β值为每年 0 msec，=.83）或性别（在 1.5 T 时，β值为-1 msec，=.88；在 3.0 T 时，β值为 6 msec，=.42）的任何关联。结论 健康成年人的 T2 弛豫时间汇总平均值在研究之间存在明显的异质性，场强、供应商和脉冲序列被确定为与 T2 相关的协变量。在每个场强下，T2 准备测量值在供应商之间是相似的。 © 2020 RSNA
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