Grove D I, Mahmound A A, Warren K S
Int Arch Allergy Appl Immunol. 1977;54(5):422-7. doi: 10.1159/000231857.
Metronidazole administered orally in doses of 20 and 200 mg/kg daily suppressed granuloma formation around Schistosoma mansoni eggs which were injected intravenously and lodged in the pulmonary microvasculature of mice. The same doses did not suppress granuloma formation in animals which had previously been sensitized to the eggs. Nonspecific granulomatous inflammation around divinyl benzene copolymer beads was unaffected by the drug. In a daily dose of 20 mg/kg, metronidazole inhibited delayed footpad reactions to soluble schistosome egg antigen, but 200 mg/kg on alternate days failed to suppress skin allograft rejection. The drug appears to suppress selectively some aspects of cell-mediated immunity.
每日口服剂量为20毫克/千克和200毫克/千克的甲硝唑可抑制静脉注射并寄生于小鼠肺微血管中的曼氏血吸虫卵周围的肉芽肿形成。相同剂量对先前已对虫卵致敏的动物的肉芽肿形成没有抑制作用。二乙烯基苯共聚物珠周围的非特异性肉芽肿性炎症不受该药物影响。甲硝唑每日剂量为20毫克/千克时，可抑制对可溶性血吸虫卵抗原的迟发型足垫反应，但隔日服用200毫克/千克未能抑制皮肤同种异体移植排斥反应。该药物似乎选择性地抑制细胞介导免疫的某些方面。
