Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center College of Pharmacy , Memphis, TN, USA.
Department of Pharmacy Science, University of Tennessee Health Science Center College of Pharmacy , Memphis, TN, USA.
Expert Opin Drug Metab Toxicol. 2020 Nov;16(11):1005-1018. doi: 10.1080/17425255.2020.1814737. Epub 2020 Aug 31.
While considerable progress has been made in the fight against HIV/AIDS, to date there has not been a cure, and millions of people around the world are currently living with HIV/AIDS. People living with HIV/AIDS have substance abuse disorders at higher rates than non-infected individuals, which puts them at an increased risk of drug-drug interactions.
Potential drug-drug interactions are reviewed for a variety of potential drugs of abuse, both licit and illicit. These drugs include alcohol, cigarettes or other nicotine delivery systems, methamphetamine, cocaine, opioids, and marijuana. Potential interactions include decreased adherence, modulation of drug transporters, or modulation of metabolic enzymes. We also review the relative incidence of the use of these drugs of abuse in People living with HIV/AIDS.
Despite considerable improvements in outcomes, disparities in outcomes between PLWHA who use drugs of abuse, vs those who do not still exist. It is of critical necessity to improve outcomes in these patients and to work with them to stop abusing drugs of abuse.
尽管在防治艾滋病毒/艾滋病方面取得了相当大的进展，但迄今为止仍未找到治愈方法，目前全球仍有数百万艾滋病毒/艾滋病感染者。与未感染者相比，艾滋病毒/艾滋病感染者滥用药物的情况更为严重，这使他们面临更多的药物相互作用风险。
本文综述了各种潜在滥用药物（包括合法和非法药物）的潜在药物相互作用。这些药物包括酒精、香烟或其他尼古丁输送系统、冰毒、可卡因、阿片类药物和大麻。潜在的相互作用包括降低药物的依从性、药物转运体的调节或代谢酶的调节。我们还回顾了这些滥用药物在艾滋病毒/艾滋病感染者中的相对使用频率。
尽管在结果方面取得了相当大的改善，但滥用药物的艾滋病毒/艾滋病感染者与未滥用药物者之间的结果仍存在差距。改善这些患者的结果并与他们合作以停止滥用药物是至关重要的。
