Verrucous antral gastritis in relation to infection, nutrition, and gastric atrophy.

BACKGROUND

There have been few studies in the English literature regarding verrucous gastritis (VG). The present study investigated the clinical and endoscopic features of verrucous antral gastritis, especially focusing on infection, nutrition, and gastric atrophy.

METHODS

We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative groups. VG was subdivided into classical and numerous types based on the number and distribution of verrucous lesions. Demographic, clinical, and endoscopic data including body mass index (BMI), serum albumin and cholesterol, gastric atrophy, reflux oesophagitis, Barrett's oesophagus, and status were collected. Univariate and multivariable analyses were performed to identify factors associated with VG.

RESULTS

We analysed the data of 621 patients undergoing routine endoscopy and found that VG (=352) was significantly associated with increased BMI (1.12 [1.05-1.18], <0.01), reflux esophagitis (1.96 [1.10-3.28], <0.01), and negativity with or without a history of eradication (9.94 [6.00-16.47] and 6.12 [3.51-10.68], <0.001, respectively). Numerous-type (=163) VG was associated with both closed- and open-type gastric atrophy (9.9 [4.04-21.37] and 8.10 [3.41-19.24], <0.001, respectively). There were no statistical differences between groups regarding age, sex, total cholesterol, albumin, and bile-colored gastric juice.

CONCLUSIONS

Verrucous antral gastritis was related to increased BMI, reflux esophagitis, and negativity. Numerous-type verrucous lesions were associated with gastric atrophy. These indicate that VG may be a physiological phenomenon due to high gastric acidity, mechanical overload, and vulnerability of background mucosa.