National Centre for Macromolecular Hydrodynamics (NCMH), School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Eur Biophys J. 2020 Dec;49(8):791-798. doi: 10.1007/s00249-020-01451-y. Epub 2020 Aug 25.
The 6-deoxy-6-aminocelluloses-or "aminocelluloses"-are a class of synthetic natural cellulose derivatives which are mostly aqueous soluble and have excellent film-forming properties. Recent studies have connected these properties at the molecular level with protein-like self-associative behaviour for a range of aminocelluloses including a 6-deoxy-6-(ω-aminoethyl) aminocellulose AEA-1 with the association being a two-stage process-a reversible oligomerisation followed by further (semi-reversible) aggregation into larger structures. Here, we synthesise and compare a new 6-deoxy-6-(ω-aminoethyl) aminocellulose AEA-1' with different degree of substitution with one with further alkyl derivatisation, namely 6-deoxy-6-(ω-hydroxyethyl) aminocellulose HEA-1'. As with AEA-1, sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge still show a two-stage process for both AEA-1' and HEA-1', with the latter giving higher molar masses. The consequences of these properties for use as consolidants for archaeological wood are considered.
6-脱氧-6-氨基纤维素，或“氨基纤维素”，是一类人工合成的天然纤维素衍生物，大多为水溶性，具有极好的成膜性能。最近的研究在分子水平上把这些性质与类似蛋白质的自组装行为联系起来，研究了一系列氨基纤维素，包括 6-脱氧-6-(ω-氨基乙基)氨基纤维素 AEA-1，其自组装过程为两步，先是可逆的低聚物化，然后进一步（半可逆）聚集形成较大的结构。在这里，我们合成并比较了具有不同取代度的新型 6-脱氧-6-(ω-氨基乙基)氨基纤维素 AEA-1'和进一步烷基化的 6-脱氧-6-(ω-羟乙基)氨基纤维素 HEA-1'。与 AEA-1 一样，分析超速离心沉降速度和沉降平衡仍显示出 AEA-1'和 HEA-1'的两步过程，后者给出了更高的摩尔质量。还考虑了这些性质在作为考古木材加固剂方面的应用。
