Mostello L, Stueber K, Lake C R
Department of Anesthesiology, University of Maryland Hospital, Baltimore.
Ann Plast Surg. 1988 Apr;20(4):313-6. doi: 10.1097/00000637-198804000-00003.
Topical epinephrine is useful in controlling the bleeding of skin graft donor sites. However, the use of exogenous epinephrine during halothane anesthetization increases the risk of cardiac arrhythmias. This study shows that there is no significant increase in plasma epinephrine levels after topical administration of up to 80 cc of 1:500,000 epinephrine, suggesting that the use of this dose in conjunction with halothane anesthesia is safe.
局部使用肾上腺素有助于控制皮肤移植供区的出血。然而，在氟烷麻醉期间使用外源性肾上腺素会增加心律失常的风险。本研究表明，局部应用高达80毫升1:500,000的肾上腺素后，血浆肾上腺素水平无显著升高，这表明该剂量与氟烷麻醉联合使用是安全的。
