Department of MRI, Xinle City Hospital, Xinle, Hebei, China.
Department of Infectious Diseases, Xinle City Hospital, Xinle, Hebei, China.
Brain Behav. 2020 Oct;10(10):e01758. doi: 10.1002/brb3.1758. Epub 2020 Aug 25.
To study the changes of white matter tracts in precentral gyrus and postcentral gyrus during normal brain aging process by analyzing fractional anisotropy (FA) values obtained from diffusion tensor imaging (DTI) technology.
Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were conducted on 120 healthy right-handed subjects. The subjects were separated into four age groups, namely Young Male/Female (<45 years old) and Senior Male/Female (>45 years old). Each subject undertakes routine MRI and DTI scans. Left/right precentral and left/right postcentral gyrus are automatically detected on the image. The area for region of interest (ROI) is set to be 18 ± 2 mm .
For each age group, the FA values of white matter in precentral gyrus and postcentral gyrus are statistically different (p < .05) in both left and right sides of the brain across different age groups and genders. Additionally, the FA values are statistically different (p < .05) between two young and senior age groups across different genders, brain regions, and hemispheres.
The FA values of precentral gyrus and postcentral gyrus are statistically different across genders, age groups, and hemispheres. Additionally, the FA values of both precentral gyrus and postcentral gyrus decrease over time, which is a strong indication of aging.
通过分析弥散张量成像（DTI）技术获得的各向异性分数（FA）值，研究中央前回和中央后回白质束在正常大脑老化过程中的变化。
对 120 名健康右利手受试者进行磁共振成像（MRI）和弥散张量成像（DTI）检查。受试者分为 4 个年龄组，即青年男性/女性（<45 岁）和老年男性/女性（>45 岁）。每位受试者均接受常规 MRI 和 DTI 扫描。在图像上自动检测左/右中央前回和左/右中央后回。将感兴趣区（ROI）的面积设置为 18±2mm。
对于每个年龄组，大脑左右两侧的中央前回和中央后回白质的 FA 值在不同年龄组和性别之间均存在统计学差异（p<.05）。此外，在不同性别、脑区和半球中，年轻和老年两个年龄组之间的 FA 值也存在统计学差异（p<.05）。
中央前回和中央后回的 FA 值在性别、年龄组和半球之间存在统计学差异。此外，中央前回和中央后回的 FA 值随时间逐渐降低，这强烈表明存在老化现象。
