Goldberg G I, Eisen A Z, Bauer E A
Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110.
Arch Dermatol. 1988 May;124(5):737-41.
Cutaneous carcinomas often arise in patients with severe epidermolysis bullosa (or other cutaneous ulcers) at multiple primary sites. Chronic tissue stress thus appears to promote carcinogenesis in preexisting somatic mutants in a stem cell population. Altered contractile properties of fibroblasts cultured from skin with epidermolysis bullosa may result from an altered interaction of these cells with their surrounding, chronically stressed, connective tissue matrix.
皮肤癌通常发生在患有严重大疱性表皮松解症（或其他皮肤溃疡）的患者的多个原发部位。因此，慢性组织应激似乎会促进干细胞群体中已有的体细胞突变体发生癌变。从患有大疱性表皮松解症的皮肤中培养的成纤维细胞收缩特性的改变，可能是由于这些细胞与其周围长期受到应激的结缔组织基质之间的相互作用发生了改变。
