Gupta M K
Department of Immunopathology, Cleveland Clinic Foundation, Ohio.
Clin Lab Med. 1988 Jun;8(2):303-23.
Graves' disease is characterized by the presence of autoantibodies with variable reactivities to TSH receptor protein. These autoantibodies are heterogeneous in nature and may act as TSH agonists or infrequently as TSH antagonists (blocking antibodies). With new technical advances, it has become possible to quantitate these antibodies and their reactivities in clinical laboratories. Technical aspects of these assays and their clinical utility in the diagnosis and management of patients with Graves' disease are discussed.
格雷夫斯病的特征是存在对促甲状腺激素（TSH）受体蛋白具有不同反应性的自身抗体。这些自身抗体本质上是异质性的，可能作为TSH激动剂起作用，或偶尔作为TSH拮抗剂（阻断抗体）起作用。随着技术的新进展，在临床实验室中对这些抗体及其反应性进行定量已成为可能。本文讨论了这些检测方法的技术方面及其在格雷夫斯病患者诊断和管理中的临床应用。
