Moncayo Samuel, Insenser María, Martínez-García M Ángeles, Fuertes-Martín Rocío, Amigó-Grau Núria, Álvarez-Blasco Francisco, Luque-Ramírez Manuel, Correig-Blanchar Xavier, Escobar-Morreale Héctor F
Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), E-28034, Madrid, Spain.
BiosferTeslab SL, Universitat Rovira i Virgili, IISPV, CIBERDEM, E-43201, Reus, Spain.
Clin Nutr. 2021 Mar;40(3):1241-1246. doi: 10.1016/j.clnu.2020.08.006. Epub 2020 Aug 14.
Acute-phase glycoprotein H-NMR spectroscopy profiles serve as surrogate markers of chronic inflammation in metabolic disorders such as obesity, diabetes and polycystic ovary syndrome (PCOS). The latter is associated with increased height-to-width (H/W) ratios of GlycA and GlycB after fasting, but not to glycoprotein areas, regardless of obesity. We studied the responses to separate glucose, lipid and protein oral challenges of five glycoprotein variables (GlycA, GlycB, and GlycF areas and the GlycA and GlycB H/W ratios) in 17 women with PCOS, 17 control women, and 19 healthy men. Glucose and protein ingestion resulted into decreases in all glycoprotein variables, whereas lipid ingestion increased GlycA, GlycF and induced minimal changes in GlycB and GlycB H/W. We found no effects of obesity or group of subjects on postprandial glycoprotein variables regardless of the macronutrient being ingested. However, a statistically significant interaction indicated that obesity blunted the decrease in some of these variables in control women and men, whereas obese women with PCOS showed larger changes when compared with their non-obese counterparts. In conclusion, acute-phase glycoprotein profiles indicate an anti-inflammatory response during postprandial phase that is less pronounced after lipid ingestion, and is counteracted by the chronic inflammatory background associated with obesity and PCOS.
急性期糖蛋白的核磁共振波谱特征可作为肥胖、糖尿病和多囊卵巢综合征（PCOS）等代谢紊乱中慢性炎症的替代标志物。尽管存在肥胖情况，但后者与空腹后GlycA和GlycB的高宽（H/W）比值增加有关，而与糖蛋白面积无关。我们研究了17名PCOS女性、17名对照女性和19名健康男性对单独的葡萄糖、脂质和蛋白质口服激发试验中五个糖蛋白变量（GlycA、GlycB和GlycF面积以及GlycA和GlycB的H/W比值）的反应。摄入葡萄糖和蛋白质导致所有糖蛋白变量降低，而摄入脂质则使GlycA、GlycF增加，并使GlycB和GlycB的H/W产生最小变化。无论摄入的常量营养素是什么，我们发现肥胖或受试者组对餐后糖蛋白变量均无影响。然而，具有统计学意义的交互作用表明，肥胖减弱了对照女性和男性中某些变量的降低，而患有PCOS的肥胖女性与非肥胖女性相比变化更大。总之，急性期糖蛋白特征表明餐后阶段存在抗炎反应，在摄入脂质后这种反应不太明显，并且受到与肥胖和PCOS相关的慢性炎症背景的抵消。
