阿巴西普会诱发睾丸毒性吗？
Does Abatacept Induce Testicular Toxicity?
作者信息
Al-Mogairen Sultan
机构信息
Department of Medicine, Division of Rheumatology, King Saud University, Riyadh, Saudi Arabia.
出版信息
Arch Rheumatol. 2020 Feb 7;35(2):220-225. doi: 10.46497/ArchRheumatol.2020.7164. eCollection 2020 Jun.
OBJECTIVES
This study aims to demonstrate the effect of subcutaneous injections of abatacept on the histology of testes in mice.
MATERIALS AND METHODS
The study included 20 male BALB/c mice (average weight, 25 g; aged 12-14 weeks). Ten mice received subcutaneous (SC) injections of abatacept [0.25 mg per 25 g body weight per 0.03 mL normal saline (NS)] at zero, two, four and eight weeks. As the control group, 10 mice received SC injections of NS (0.03 mL). At the post-injection 10 week, the mice were sacrificed, and histopathological studies were conducted.
RESULTS
The results showed that 3/10 mice died of the abatacept-treated group. Testicular histology for the abatacept-treated group showed that 7/7 displayed no histopathological changes.
CONCLUSION
To our knowledge, this is the first control-blinded study of BALB/c mice suggesting that abatacept may not have testicular toxicity. Further fertility and testicular toxicology evaluations including semen analysis and gonadal hormones should be performed to clarify our findings.
目的
本研究旨在证明皮下注射阿巴西普对小鼠睾丸组织学的影响。
材料与方法
该研究纳入20只雄性BALB/c小鼠（平均体重25 g；年龄12 - 14周）。10只小鼠在第0、2、4和8周接受皮下注射阿巴西普[每25 g体重0.25 mg阿巴西普溶于0.03 mL生理盐水（NS）]。作为对照组，10只小鼠接受皮下注射生理盐水（0.03 mL）。在注射后第10周，处死小鼠并进行组织病理学研究。
结果
结果显示，阿巴西普治疗组中有3/10的小鼠死亡。阿巴西普治疗组的睾丸组织学检查显示，7/7未出现组织病理学变化。
结论
据我们所知，这是第一项针对BALB/c小鼠的对照盲法研究，表明阿巴西普可能没有睾丸毒性。应进行进一步的生育力和睾丸毒理学评估，包括精液分析和性腺激素检测，以阐明我们的研究结果。
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